hypoglycin


Also found in: Wikipedia.

hypoglycin

A toxic amino acid derived from the unripe ackee fruit, which evokes hypoglycaemia and inhibits the catabolism of branched-chain amino acids and the other symptoms of Jamaican vomiting sickness.
References in periodicals archive ?
Horses suffering from atypical myopathy have high levels of a toxin called hypoglycin that prevents energy being produced
Recent research showed it is caused by the toxin hypoglycin A that is contained sycamore seeds.
The serum levels of PSDP, lysoPCs, 3D, 7D, 11D-phytanic acid, behenic acid, hypoglycin B, phytal and threoninyl-a-glutamate were significantly different between the active TB and lung cancer subgroups ( ?
In Muzaffarpur, MCPG is hypothesized to cause acute hypoglycemia and illness through a similar mechanism to hypoglycin A, a toxin that has been reported to cause acute encephalopathy in the West Indies and West Africa after consumption of unripe ackee, a fruit in the same botanical family as litchi (6-9).
Hypoglycin A and B isolated from the fruits of Blighia sapida, which are chemically related to lysine were reported for their anti-hyperglycemic activity (Hassall and Reyle, 1954; Feng and Patrick, 1958).
Hypoglycin A, B: biologically active polypeptides from Blighia sapida.
The toxin is called hypoglycin A and it is present, in varying concentrations, in the leaves and the helicopter-shaped seeds; there is evidence that the weather can affect the level of toxin produced by the tree and not all seeds contain the same level.
There is no antidote for hypoglycin A poisoning - treatment consists of managing the effects of the poison on the body, flushing out the horse's system and maintaining hydration to prevent further damage.
When the fruit is still unripe, it contains a toxin, hypoglycin A, or HGA, that sickens anyone who dares to eat it.
Selective Inhibition of Acyl-CoA Dehydrogenases by a Metabolite of Hypoglycin.
where he first became interested in the chemistry of strained rings related to the hypoglycemic agent, hypoglycin.
Unripe ackee contains hypoglycin A, a water-soluble liver toxin that induces hypoglycemia by inhibiting gluconeogenesis secondary to its limiting of cofactors (CoA and carnitine) essential for oxidation of long-chain fatty acids ( 1,4 ).