hypogangliosis, hypoganglionosis

deficiency in the number of myenteric ganglion cells, usually in the colon leading to the development of megacolon. See also aganglionosis.

Clydesdale myenteric hypogangliosis
megacolon develops at about 4-9 months old. Possibly an inherited trait.
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References in periodicals archive ?
Histology revealed severe regional hypogangliosis and crypt architecture distortion (Figure 3).
8) Decreases in ICC density have also been implicated in other forms of adult GINMD, notably hypogangliosis and slow transit constipation, (9-12) while adult Hirsphrung's is associated with a lack of function or absence of ganglionic cells in colonic myenteric plexus.