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hypoganglionosis

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hypoganglionosis /hy·po·gan·gli·o·no·sis/ (-gang″gle-on-o´sis) lessened number of myenteric ganglion cells in the distal large bowel, with constipation; a congenital type of megacolon.
hy·po·gan·gli·on·o·sis (hp-gnggl--nss)
n.
A reduction in the number of ganglionic nerve cells, especially of the ganglia of the myenteric plexus.

hypoganglionosis [hi″po-gang″gle-o-no´sis]
deficiency in the number of myenteric ganglion cells in the distal segment of the large bowel, resulting in constipation; a variant of congenital megacolon.

hypogangliosis, hypoganglionosis
deficiency in the number of myenteric ganglion cells, usually in the colon leading to the development of megacolon. See also aganglionosis.

Clydesdale myenteric hypogangliosis
megacolon develops at about 4-9 months old. Possibly an inherited trait.


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In one case, myenteric hypoganglionosis and reduction in numbers of interstitial cells of Cajal were observed.
 
 
 
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