hypofibrinogenemia


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hypofibrinogenemia

 [hi″po-fi-brin″o-jĕ-ne´me-ah]
deficiency of fibrinogen in the blood; called also fibrinogenopenia. See also afibrinogenemia.

hy·po·fi·brin·o·ge·ne·mi·a

(hī'pō-fī-brin'ō-jĕ-nē'mē-ă),
Abnormally low concentration of fibrinogen in the circulating blood plasma.

hypofibrinogenemia

/hy·po·fi·brin·o·gen·emia/ (-fi-brin″o-jĕ-ne´me-ah) deficiency of fibrinogen in the blood.

hypofibrinogenemia

[-fī′brinōjənē′mē·ə]
Etymology: Gk, hypo + L, fibra, fiber; Gk, genein, to produce, haima, blood
plasma fibrinogen deficiency. It may be inherited or acquired, as in disseminated intravascular coagulation or liver disease. Also spelled hypofibrinogenaemia.

hypofibrinogenemia

↓ Fibrinogen in circulation. See Congenital afibrionogenemia.

hy·po·fi·brin·o·ge·ne·mi·a

(hī'pō-fī-brin'ō-jĕ-nē'mē-ă)
Abnormally low concentration of fibrinogen in the circulating blood plasma.
Synonym(s): hypofibrinogenaemia.

hypofibrinogenemia (hī´pōfīb-rin´ōjənē´mēə),

n a reduction of fibrinogen in the blood. Excessive bleeding may occur following trauma. The deficiency of fibrinogen may be congenital or may result from faulty synthesis associated with liver disease and defibrinogenation resulting from disorders of pregnancy involving the placenta and amniotic fluid. The normal range is 200 to 600 mg/100 ml of plasma. Clot-ting deficiencies do not occur until the concentration falls below 75 mg/100 ml.

hypofibrinogenemia

deficiency of fibrinogen in the blood. Has been reported as an inherited defect in St. Bernard dogs; is acquired in liver disease and as a sequel of disseminated intravascular coagulation.
References in periodicals archive ?
5 2) Splenomegaly 3) Cytopenias (affecting at least 2 of 3 lineages in the peripheral blood) 4) Hypertriglyceridemia (>265 mg/dL, fasting) and/or hypofibrinogenemia (<150 mg/dL) 5) Hemophagocytosis in bone marrow, spleen, lymph nodes, or liver 6) Low or absent NK-cell activity 7) Ferritin >500 ng/mL 8) Elevated soluble CD25 (alpha chain of soluble IL-2 receptor)
In the present case, there were features of severe malaria in the form of fever, altered sensorium, and hypotension with pancytopenia, hyperferritenemia, hypertriglyceridemia and hypofibrinogenemia due to he mophagocytic syndrome which was confirmed by bone marrow examination.
Important criteria for selecting a TT reagent are high sensitivity to heparin, sensitivity to hypofibrinogenemia, and acceptable precision.
All patients fulfilled at least five cardinal criteria of HLH at the time of diagnosis, including fever, hepatosplenomegaly, bicytopenia and/or pancytopenia, hypertriglyceridemia and/or hypofibrinogenemia, hyperferritinemia, and hemophagocytosis in the bone marrow, liver or lymph nodes (10).
Although decreases in fibrinogen concentrations during CPB are generally clinically insignificant [2,22-241, excessive plasmin activity may lead to hypofibrinogenemia, fibrinogen/ fibrin degration product-mediated platelet dysfunction X15], and degradation of factors V, VIII, and XIII [25].
5 g/dl, platelet: 77000/mm3), hypertriglyceridemia (351 mg/ dl), hyperferritinemia (>1500 ng/dl) and hypofibrinogenemia (120 mg/dl) were detected.
Because of myelosuppression, which was unexpected from chemotherapy, hyperbilirubinemia, hypertriglyceridemia, and hypofibrinogenemia, the patient was thought to have HPS.
Hemophagocytic lymphohistiocytosis (HLH) is characterized by fever, hepatosplenomegaly, cytopenia, hyperferritinemia, hypertriglyceridemia, and/or hypofibrinogenemia, increased CD 25 level, and decreased natural killer activity [1].
This extrinsically activated test includes the addition of a platelet inhibitor (cytochalasin D) to differentiate between hypofibrinogenemia and thrombocytopenia in bleeding patients who demonstrate a weak clot formation.
Blood analysis findings were thrombocytopenia (platelet count: 87 x 10[degrees]/L), hypofibrinogenemia, and a high D-dimer level (5000ng/mL [normal: 147 ng/mL]).
RiaSTAP was approved by the FDA in January and is indicated for the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia.
During our investigations of the molecular basis of dysfibrinogenemia and hypofibrinogenemia, we noted an additional B[beta] peak at -130 Da in a control sample from a patient with pancreatitis.