Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia
2007) Familial hypercholesterolemia associated with severe hypoalphalipoproteinemia
in a Moroccan family.
is a common finding in patients with premature CAD (present in about 5% of these patients).
Concentrations of apolipoprotein A-I-containing particles in patients with hypoalphalipoproteinemia
Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia
and kidney hypercatabolism of apoA-I.
Apo A-IMALLORCA impairs LCAT activation and induces dominant familial hypoalphalipoproteinemia
Postprandial lipoprotein(a) response to a single meal containing either saturated or omega-3 polyunsaturated fatty acids in subjects with hypoalphalipoproteinemia
The carrier state of deleterious mutations in the ABCA1 gene has also been found to be the cause of familial hypoalphalipoproteinemia
(FHA), which is characterized by low serum HDL-C (150-350 mg/L) (7).
Despite the recent characterization of ABCA1 mutations as the cause of Tangier disease (TD) and familial hypoalphalipoproteinemia
(2-5), there have been little data evaluating clinical measures of atherosclerosis in individuals with identified defects in ABCA1.
Agreement with BQ was reasonable in specimens from individuals with normocholesterolemia, combined hyperlipidemia, or isolated hypoalphalipoproteinemia
(94); in contrast, hypercholesterolemia produced a negative bias (-5.
A zinc finger transcription factor (ZNF202) located within a hypoalphalipoproteinemia
locus on chromosome 11q23 acts as a strong repressor on ABCA1 expression and cellular lipid efflux (12).
The patient had no signs or symptoms such as large orange tonsils, corneal opacities, or relapsing polyneuropathy, compatible with primary hypoalphalipoproteinemia