hypervariable regions

hy·per·var·i·a·ble re·gions

(hī-per'var-ī-a-ble),
the regions of the immunoglobulin molecule that contain most of the residues involved in the antibody binding site. Hypervariability at the site of antigen building ensures the broadest immunologic repertoire.

hypervariable regions

The parts within the antibody and T cell receptor variable regions which show the greatest variability.
References in periodicals archive ?
Bacterial 16S rRNA gene possesses 9 hypervariable regions flanked by highly conserved regions, which are generally designated as polymerase chain reaction (PCR) primer sites.
com)-- The NEXTflex[TM] 18S ITS Amplicon-Seq Kit simplifies the preparation of multiplexed amplicon libraries spanning the ITS1 and ITS2 hypervariable regions of eukaryotic 18S ribosomal RNA (rRNA) genes to permit the fast and cost-effective characterization of uncultured fungal and micro-eukaryotic organisms.
None of the sequences of the wsp hypervariable regions (HVR) from wAna were different from those sequences previously reported in the Wolbachia MLST database (HVR1 = 11, HVR2 = 9, HVR3 = 15, HVR4 = 25).
The mtDNAPlus product tests Hypervariable Regions 1 and 2, or HVR1 and HVR2, providing individuals with both anthropological and genealogical information.
dNa sequencing of hypervariable regions I and II of mtDNA identified 54 different haplotypes defined by 88 transitions and 4 transversions in 92 variable sites.
Using these methods, his team found that C05 effectively avoids grabbing the hypervariable regions around the flu RBS.
Polymerase chain reaction (PCR) was used to amplify the bacterial genes from the first 2 hypervariable regions of the 16s ribosomal RNA using universal primers 27F (5'-AGA GTT TGA TCM TGG CTC AG-Y) and 355R (5'-GCT GCC TCC CGT AGG AGT-3') (InvitrogenTM Corporation, Carlsbad, CA).
The 16s rDNA sequence has hypervariable regions, where sequences have diverged over evolutionary times and classification of organisms can be easily done.
Cleavage of the HCV PCR product by such enzymes yields multiple oligonucleotide fragments of defined length representing hypervariable regions of HCV.
The near-infinite range of antigen specificity is determined by changes in short, looping sequences called hypervariable regions, so researchers can concentrate on these smaller bits of the amino acid sequence.
Modification of Ad5 Hexon Hypervariable Regions Circumvents Pre-existing Ad5 Neutralizing Antibodies" will be presented on Saturday, the 31st of May.