hypervariable regions

hy·per·var·i·a·ble re·gions

(hī-per'var-ī-a-ble),
the regions of the immunoglobulin molecule that contain most of the residues involved in the antibody binding site. Hypervariability at the site of antigen building ensures the broadest immunologic repertoire.

hypervariable regions

The parts within the antibody and T cell receptor variable regions which show the greatest variability.
References in periodicals archive ?
Employing 18S hypervariable regions as molecular markers, we show a sequence analysis of (V3, V4 and V9) hyper-variable regions of the small sub unit (SSU) of different natural strains of the Pyrenomycete, Sordaria fimicola, to examine genetic diversity.
The 16S rRNA gene sequence has a characteristic organization, with 9 hypervariable regions separating 10 conserved regions (Figure 1) [9,26].
Positive specimens were molecularly typed, based on sequencing of hexon hypervariable regions 1-6 and inoculated into A549 cells for virus isolation.
Humanized antibodies are produced by grafting murine hypervariable regions on amino acid domains into human antibodies.
To test this, we considered a large genetic data set of two hypervariable regions (V5 and V6), from previously generated barcoded 16S ribosomal (rDNA) amplicons from microbialite communities distributed in different geographical regions of Mexico.
The molecular methods used for typing HAdVs in this study targeted the hexon hypervariable regions that have been shown to correlate closely with virus serotype.
Antigen-antibody reactions involve complementary binding between an antigen molecule surface epitope and hypervariable regions of antibody molecules [18].
The typing kit targets the most hypervariable regions of the MHC class I and class II genes.
Crawford-Miksza and Schnurr (1996) reported that the hypervariable regions of hexon gene carries type specific antigentic determinants and are hotspots' for recombination.
This fragment is interspersed by six hypervariable regions entailing a phylogenetic signal able to resolve relationships within foraminiferal clades and down to the species level (Pawlowski and Lecroq, 2010).
13) By mutagenesis of the third hypervariable regions of the light and heavy chains we obtained three antibodies with 3-4 times increased avidity for antigen.