By blocking the expression of a certain gene in patients, University of Montreal researchers have contributed to the demonstration of great decreases in the concentration of triglycerides in their blood, even in severe forms of hypertriglyceridemia
and regardless of the base values or the treatment the patient usually receives.
The company's lead product candidate, MAT9001, is a uniquely engineered and proprietary prescription-only omega-3 fatty acid composition, comprised of a complex mixture of omega-3 fatty acids, including docosapentaenoic acid (DPA), a highly potent and less prevalent omega-3 fatty acid, eicosapentaenoic acid (EPA), several other omega-3 fatty acids, and only trace amounts of docosahexaenoic acid (DHA) which is under development for therapeutic applications, with severe hypertriglyceridemia
(TG>500 mg/dL) as the lead indication.
However, niacin may still have a role in patients at very high risk for cardiovascular events who truly have contraindications to statins and other less toxic drugs, and as a possible fourth-line agent for patients with severe hypertriglyceridemia
who are at risk for developing pancreatitis, he added.
The US Food and Drug Administration (FDA) have given authorization of Epanova, AstraZeneca s treatment for adults with the condition hypertriglyceridemia
Fenoget is indicated as adjunctive therapy to diet for the treatment of adult patients with hypertriglyceridemia
(Fredrickson types IV and V hyperlipidemia", they said.
is a complication of acromegaly.
s subsidiaiy, has released positive results for its Phase II trial designed to assess the safety and efficacy of its investigational new drug candidate CaPre in the treatment of mild to severe hypertriglyceridemia
His past medical history includes hypertriglyceridemia
and hepatosteatosis for 3 years.
The US firm, based in Princeton, New Jersey, is expected to file a new drug application soon for use of the drug for patients with severe hypertriglyceridemia
, with applications in other markets to follow.
According to Sinha, the genetic disorder could have led to any of the suspected diseases, such as glycogen storage which is normally diagnosed in one among 20,000 new-born babies, Tay-Sachs, Niemann-Pick or familial hypertriglyceridemia
, all related to problems of metabolism.
has been shown to be one of the risk factors for prostate cancer.
The patient's other diagnoses were hypertriglyceridemia
, chronic kidney disease, and diabetes.