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hypersusceptibility

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hypersusceptibility (hī´purs-sep´tibil´itē),
n a condition of abnormal susceptibility to poisons, infective agents, or agents that are entirely innocuous in the normal individual.


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PATHWAYS OF TENOFOVIR RESISTANCE The K65R mutation in reverse transcriptase confers resistance to tenofovir and intermediate levels of cross-resistance to abacavir, didanosine, and lamivudine, and also has resistance effects for stavudine (not evident in phenotypic testing), while conferring hypersusceptibility to zidovudine.
Hypersusceptibility to cisplatin carcinogenicity in metallothioneinI/II double knockout mice: production of hepatocellular carcinoma at clinically relevant doses.
Generally, the biologic price to pay for extending the substrate range of this enzyme is hypersusceptibility to [beta]-lactamase inhibitors.
 
 
 
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