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hypersusceptibility

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hypersusceptibility (hī´purs-sep´tibil´itē),
n a condition of abnormal susceptibility to poisons, infective agents, or agents that are entirely innocuous in the normal individual.

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Hypersusceptibility to cisplatin carcinogenicity in metallothioneinI/II double knockout mice: production of hepatocellular carcinoma at clinically relevant doses.
Generally, the biologic price to pay for extending the substrate range of this enzyme is hypersusceptibility to [beta]-lactamase inhibitors.
And now we have a third version of the story, which is if you use atazanavir first and get rebound, you actually get hypersusceptibility of the virus to other protease inhibitors--meaning that the virus is more susceptible to the drugs (at least predicted, based on the mutations seen).
 
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