The investigators showed further that the macrolide antibiotic clarithromycin, a negative allosteric modulator of GABA-A receptors, reduced sleepiness in patients with central hypersomnolence
syndromes in a randomized, double-blind, crossover trial (Ann Neurol.
33) All muscle relaxants are limited by side effects of fatigue and hypersomnolence
In primary CSA, daytime hypersomnolence
is less common than with OSA, although such daytime sleepiness has been commonly described in patients with central apnoea (74).
I usually start my interview of patients with hypersomnolence
with very careful, nonleading [questions about] cataplexy, because if the cataplexy is present, you have your diagnosis," Dr.
Bresch's critique, I think we should explore further the possibility that this patient may have delirium/sleep related ictal events on very high doses of clozapine; psychosis at lower doses; and a sleep disorder that has features of narcolepsy after a relative pharmacological wash out, remission of his psychotic symptoms, and improvements in drug induced sedation and hypersomnolence
The patient should also be observed for confusion, especially upon awakening, and hypersomnolence
during the day (inability to stay awake, falling asleep during a conversation or at other inappropriate times).
A diagnosis of SAS was established by the simultaneous presence of two criteria: subjective hypersomnolence
, defined as >10 points on the Epworth sleepiness scale, and an increased apnea-hypopnea index, defined as more than five apnea or hypopnea episodes per hour of sleep during an overnight sleep study.
Her husband reported that she was a snorer, but she did not complain of significant daytime hypersomnolence
dagger]) Somnolence includes adverse event terms: hypersomnia, hypersomnolence
, sedation, and somnolence.
Myotonic dystrophy--the most common adult form of muscular dystrophy--is a chronic, progressive, and inherited neuromuscular condition presenting with multisystemic complications including distal muscle weakness, myotonia, hypersomnolence
, early-onset cataracts, cardiac conduction abnormalities, and slurred speech and swallowing problems (Harper, 2001).
In contrast, traditional stimulants may cause addiction, tolerance and abuse, and give rise to negative effects on sleep structure, thus cause rebound hypersomnolence
or "come down" effects.