Spearman rank order correlations were calculated to investigate the association between treatment duration, clozapine dose, age and adverse effects of clozapine (sedation, constipation, hypersalivation, prolongation of QTc-interval, WCC and EPSs).
According to the TNHS, the prevalence of hypersalivation was 79.
When trihexyphenidyl 5-15 mg/day was given for 15 days to 14 patients who had nocturnal clozapine drooling, a 44% reduction in hypersalivation
was reported (Int.
An improvement in psychotic symptoms and associated behavioral abnormalities was noted with clozapine but it caused hypersalivation
, constipation and a seizure disorder necessitating treatment with sodium valproate (which stopped the seizures).
Adverse events documented during admission were constipation (1 case), hypersalivation
(2 cases), seizures (1 case from the CG and 2 cases from the EG, 1 of which occurred during an ECT session, see below), sedation (1 case) and nausea (1 case).
Ultrasound-guided injections have been reported to be safe and effective in controlling hypersalivation
, but the effects fade in several months, and repeat injections are necessary.
I never add an anticholinergic except while switching; or, at bedtime, for hypersalivation
with clozapine," he said.
As we observed hypersecretion of mucus and hypersalivation
in all experimental cats during our experiments, we are sure that the antitussive activity of Emblica officinalis is first of all connected with this phenomenon.
Premortem diagnosis of rabies is difficult and relates to a number of hindering factors, including a nonspecific prodrome flulike illness, poor history of animal bite, lack of typical hydrophobia and hypersalivation
, and presentation similar to other encephalitides.
Signs and symptoms were typical of rabies, namely, fever, excitation, aerophobia, hydrophobia, dysphagia, and hypersalivation
, leading to coma and death.
Symptoms develop within 20 minutes to 3 hours of consumption, and include oral and extremity paresthesias, GI disturbance, hypersalivation
, diaphoresis, cranial nerve dysfunction, refractory hypotension, and cardiovascular collapse.
Based on response to AMDP-5 questionnaires, male patients experienced hypersalivation
, dizziness and hypotonia significantly more often among clozapine patients, and dry mouth, difficulty falling asleep, diarrhea and backache significantly more often among Zyprexa patients.