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hyperprolactinemia

   Also found in: Wikipedia 0.02 sec.
hyperprolactinemia /hy·per·pro·lac·tin·emia/ (-pro-lak″tĭ-ne´me-ah) increased levels of prolactin in the blood, often associated with pituitary adenoma.hyperprolactine´mic
hy·per·pro·lac·ti·ne·mi·a (hpr-pr-lkt-nm-)
n.
An elevated level of prolactin in the blood.

hyperprolactinemia
[-prōlak′tinē′mē·ə]
Etymology: Gk, hyper + L, pro, before, lac, milk; Gk, haima, blood
an excessive amount of prolactin in the blood, usually caused by a pituitary adenoma but sometimes caused by endocrine side effects related to certain antipsychotic medications. In women it is usually associated with galactorrhea and secondary amenorrhea; in men it may be a factor in gynecomastia, decreased libido, and impotence. Also spelled hyperprolactinaemia.

hyperprolactinemia
increased levels of prolactin in the blood; occurs in severe hypothyroidism, caused by excessive thyrotropin-releasing hormone. Galactorrhea and anestrus results.


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Women were categorized clinically as normal (either obese or nonobese), or as having hyperprolactinemia, hypothalamic amenorrhea, or polycystic ovary syndrome (PCOS) (again, either obese or nonobese).
Increased prolactin levels are often seen in people with hypothyroidism, and doctors routinely test people with hyperprolactinemia for hypothyroidism.
Ipsen has several endocrinology compounds in pre-clinical development, including two products that could enter clinical development as early as 2007: dopastatin (BIM 23A760), a chimeric molecule directed towards somatostatin and dopamine receptors, is targeted at the possible treatment of pituitary adenomas, including those causing acromegaly, Cushing's disease and hyperprolactinemia as well as non-functional pituitary adenomas.
 
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