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hyperproinsulinemia

   Also found in: Wikipedia 0.01 sec.
hyperproinsulinemia /hy·per·pro·in·su·lin·emia/ (-pro-in″sah-lĭ-ne´me-ah) elevated levels of proinsulin or proinsulin-like material in the blood.
hy·per·pro·in·su·li·ne·mi·a (hpr-pr-ns-l-nm-)
n.
Elevated levels of proinsulin or proinsulinlike material in the blood.
hyperproinsulinemia
the presence of proinsulin in excess of normal concentrations in the blood.
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In this study, total proinsulin concentrations were in accord with previously published reports of 10% (proinsulin:insulin) for samples from persons without diabetes and 20% for patients with type 2 diabetes (24), with no samples displaying inappropriate hyperproinsulinemia (25).
Comparison of II human insulin assays: implications for clinical ... by Manley, Susan E.; Stratton, Irene M.; Clark, Penelope M.; Luzio, Stephen D. / Clinical Chemistry
Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
Endocrine paradox in heart failure: resistance to biological effects ... by Clerico, Aldo; Emdin, Michele / Clinical Chemistry
However, in patients suffering from type I (10) or type II diabetes (11-13), familial hyperproinsulinemia (14,15), or insulinoma (16), the insulin concentration can be overestimated by the relatively high concentrations of proinsulin and conversion intermediates.
Highly specific radioimmunoassay for human insulin based on immune ... by Deberg, Michelle; Houssa, Paule; Frank, Bruce H.; Sodoyez-Goffaux, Francoise; Sodoyez, Jean-claude / Clinical Chemistry
 
 
 
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