hyperoxaluria


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hyperoxaluria

 [hi″per-ok″sah-lu´re-ah]
an excess of oxalates in the urine, which can lead to formation of kidney stones. Called also oxaluria.
enteric hyperoxaluria formation of calcium oxalate calculi in the urinary tract, occurring after extensive resection or disease of the ileum, due to excessive absorption of oxalate from the colon.
primary hyperoxaluria an autosomal recessive disorder characterized by urinary excretion of oxalate, with nephrolithiasis, nephrocalcinosis, early onset of renal failure, and often a generalized deposit of calcium oxalate.

hy·per·ox·a·lu·ri·a

(hī'pĕr-ok'să-lyū'rē-ă),
Presence of an unusually large amount of oxalic acid or oxalates in the urine; renal stones may occur.
Synonym(s): oxaluria

hyperoxaluria

/hy·per·ox·al·uria/ (-ok″sah-lu″re-ah) an excess of oxalates in the urine.
enteric hyperoxaluria  formation of calcium oxalate calculi in the urinary tract after resection or disease of the ileum, due to excessive absorption of oxalate from the colon.
primary hyperoxaluria  an inborn error of metabolism with defective glyoxylate metabolism, excessive urinary excretion of oxalate, nephrolithiasis, nephrocalcinosis, early onset of renal failure, and often a generalized deposit of calcium oxalate.

hyperoxaluria

(hī′pər-ŏk′sə-lo͝or′ē-ə)
n.
The presence of an unusually large amount of oxalic acid or oxalates in the urine.

hyperoxaluria

[-ok′səloo͡r′ē·ə]
an excessive level of oxalic acid or oxalates, primarily calcium oxalate, in the urine. The cause is usually an inherited deficiency of an enzyme needed to metabolize oxalic acid, which is present in many fruits and vegetables, or a disorder of fat absorption in the small intestine. An excess of oxalates may lead to the formation of renal calculi and renal failure. Treatments include pyridoxine, forced fluids, and a low-oxalate diet.

hyperoxaluria

A condition characterised by excess urinary oxalate (formula C2O4), which may lead to calcium oxalate stones in the pelvicalyceal system or urinary bladder.

Aetiology
Acute tubular necrosis, enteric hyperoxaluria, cystic fibrosis, coeliac disease, diabetes, foods (e.g., beef greens, rhubarb, spinach, beets, chard, okra, peanuts, chocolate, pecans, tea, carrots), short bowel syndrome.

Management, primary hyeroxaluria
High-dose pyridoxine, orthophosphate, magnesium, increased fluid volumes, glycosaminoglycans (pentosan polysulfate), dialysis.

Management, secondary hyeroxaluria
Calcium supplements, iron, aluminium, magnesium, potassium citrate, cholestyramine, diet (reduced fat, low meat, low oxalate foods).

hy·per·ox·a·lu·ri·a

(hī'pĕr-ok-să-lyūr'ē-ă)
Presence of an unusually large amount of oxalic acid or oxalates in the urine.
Synonym(s): oxaluria.

hy·per·ox·a·lu·ri·a

(hī'pĕr-ok-să-lyūr'ē-ă)
Presence of an unusually large amount of oxalic acid or oxalates in the urine.
Synonym(s): oxaluria.

hyperoxaluria (hī´pərok´səlŏŏr´ēə),

n an excessive level of oxalic acid or oxalates, primarily calcium oxalate, in the urine. The cause is usually an inherited deficiency of an enzyme needed to metabolize oxalic acid, which is present in many fruits and vegetables, or a disorder of fat absorption in the small intestine. An excess of oxalates may lead to the formation of renal calculi. Treatment may include pyridoxine, forced fluid, and a low-oxalate diet.
hyperoxaluria, primary,
n an inherited deficiency of the enzyme that metabolizes oxalic acid, resulting in an excessive level of oxalic acid or oxalates in the urine.

hyperoxaluria

an excess of oxalate in the urine; occurs in dogs in association with oxalate urolith formation.

primary hyperoxaluria
inherited metabolic defect in cats. Characterized by heavy deposits of oxalates in renal tubules, leading to oxalate nephrosis and fatal uremia before the patient reaches a year of age.
References in periodicals archive ?
M2 PHARMA-July 20, 2017-Dicerna Expands Lead GalXCDevelopment Program to Encompass All Forms of Primary Hyperoxaluria and Reveals New Therapeutic Target for DCR-PHXC
RNAi therapeutics company Dicerna Pharmaceuticals (NasdaqGS:DRNA) revealed on Wednesday that it has submitted an investigational new drug (IND) application to the US Food and Drug Administration (FDA) for its therapeutic candidate DCR-PH1 for the treatment of primary hyperoxaluria type 1 (PH1), a severe, rare, inherited disorder of the liver that often results in kidney failure and for which there are no approved therapies.
Although hyperoxaluria was more common in our diabetic patients, pure uric acid stones were more frequent than the mixed uric acid/calcium oxalate stones than one might have predicted given the finding of hyperoxaluria.
Primary Hyperoxaluria is a rare genetic disease in which excessive oxalate is produced by the liver and excreted in the urine by the kidneys.
ALTU-237 is being developed as an oral form of an oxalate-degrading enzyme for the treatment of primary hyperoxaluria and enteric hyperoxaluria, as well as to prevent the recurrence of kidney stones.
Documented hyperoxaluria should prompt a search for dietary indiscretions, undiagnosed bowel disease or, if substantially elevated, primary hyperoxaluria.
Doctors in Newcastle have just diagnosed the 22-month-old with primary hyperoxaluria, a life-threatening condition which affects just one in 120,000 children.
Oxalosis & Hyperoxaluria Foundation PO Box 1632 Kent, WA 98035 (206) 631-0386 1,2,4,6,7,8,9,10
Primary Hyperoxaluria is a rare condition characterized by the overproduction of a substance called oxalate, or oxalic acid.
Although the urine composition given as an example still seems to be of normooxaluric composition, the patient actually suffers from hyperoxaluria.
Biopharmaceutical company OxThera AB revealed on Wednesday the randomization of the first patient suffering from Primary hyperoxaluria (PH) under its phase III EPHEX study with Oxabact.
Alnylam Pharmaceuticals (ALNY) announced that Sanofi Genzyme (SNY) has declined its opt-in for the development and commercialization of lumasiran, or ALN-GO1, an investigational RNAi therapeutic for the treatment of Primary Hyperoxaluria Type 1.