Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.
1. hypertrophy of the horny layer of the skin, or any disease characterized by it.
2. hypertrophy of the cornea. adj., adj hyperkeratot´ic.
epidermolytic hyperkeratosis a hereditary autosomal dominant form of ichthyosis, present at birth. Characteristics include generalized redness of the skin and severe hyperkeratosis with small, hard wartlike scales over the entire body, accentuated in areas that flex or bend and sometimes involving the palms and soles. In infancy and childhood, there are recurrent bullae, most often on the lower limbs.
follicular hyperkeratosis a skin condition characterized by excessive development of keratin in hair follicles, resulting in rough, cone-shaped, elevated papules, the openings of which are often closed with a white plug of encrusted sebum. Deficiencies of vitamins A and E, B complex vitamins, and essential fatty acids have all been implicated in the etiology. Called also phrynoderma.
hyperkeratosis lenticula´ris per´stans an autosomal dominant skin disorder, usually occurring in the third or fourth decade of life, characterized by pink, red, or yellow to brown scaly papules on the lower leg and back of the foot, and sometimes on the trunk, thigh, arm, back and palm of the hand, or sole of the foot.
1. hypertrophy of the stratum corneum of the skin, or any disease so characterized.
2. hypertrophy of the cornea.
epidermolytic hyperkeratosis a hereditary disease, with hyperkeratosis, blisters, and erythema; at birth the skin is entirely covered with thick, horny, armorlike plates that are soon shed, leaving a raw surface on which scales then reform.
hyperkeratosis follicula´ris in cu´tem pe´netrans Kyrle's disease.
n. pl. hyperkerato·ses (-sēz)
Hypertrophy of the cornea or the horny layer of the skin.
hy′per·ker′a·tot′ic (-tŏt′ĭk) adj.
Etymology: Gk, hyper + keras, horn, osis, condition
hyperkeratosisDermatology An ↑ in superficial keratinized layers of certain epithelia, skin, and uterine cervix; hyperkeratosis usually represents a reaction to irritation, and generally overlies benign epithelium
hyperkeratosisUndue thickening of the outer layer of the skin so that a dense horny layer, such as a corn or callosity, results. This is a normal and essentially protective response to local pressure. Hyperkeratosis may also occur as an inherited disorder of the palms and the soles, or as ICHTHYOSIS.
Thickening of the horny layer of the epidermis or mucous membrane.
1. hypertrophy of the horny layer (stratum corneum) of the skin, or any disease characterized by it; the hyperkeratoses may have distinctive formats, e.g. annular (ring formations), basket-weave, compact, laminated.
2. hypertrophy of the cornea.
chlorinated naphthalene poisoning.
increased thickness of the keratinized epidermis of footpads in dogs and rarely cats. May be in response to trauma or associated with distemper (hardpad disease), or pemphigus foliaceus.
a form of ichthyosis in humans which is inherited as an autosomal dominant trait; there is severe degeneration of the granular layer of the epidermis.
a crusting dermatosis over bony prominences, face and chin of young dogs. See zinc-responsive dermatosis.
an abnormal thickening, sometimes with fissures, of the planum nasale of dogs. May occur in association with digital hyperkeratosis (see above) as a feature of distemper (hardpad disease). Also seen in pemphigus foliaceus and discoid lupus erythematosus.
see nasal hyperkeratosis, digital hyperkeratosis (above).
hyperkeratosis with non-nucleated cells present.
hyperkeratosis with nucleated cells present; called also parakeratosis.