The epidermis was characterized by flattening of the rete ridges, hyperkeratosis, hypergranulosis
and regular palisading basal cell layer, blood vessels were oriented vertically.
There was marked orthokeratosis, focal parakeratosis, papillomatosis, acanthosis and follicular plugging with focal hypergranulosis
The histopathological features seen with psoriatic nails were hypergranulosis
of nail bed and neutrophilic infiltrate in nail matrix.
A skin biopsy was performed, revealing alternating orthokeratosis and parakeratosis, confluent hypergranulosis
, and follicular plugging, compatible with the clinical diagnosis of pityriasis rubra pilaris.
Skin biopsy revealed hyperkeratosis, acanthosis, hypergranulosis
, large papillae with blunt rete ridges and a perivascular lymphocytic infiltration in the supra-papillary region of dermis (Fig.
These lesions have been found to be associated with lichenification, acanthosis, basal cell hyperpigmentation, hyperkeratosis, hypergranulosis
, and dermal papillary fibrosis (2).
No biopsy specimens from unaffected control legs showed hypergranulosis
Histologically, first-stage sebaceous nevi are characterized by papillomatous epidermal hyperplasia, hypergranulosis
, hyperkeratosis, and increased numbers of prickle cells.
In the present study, hyperkeratosis was the commonest (49, 98%) finding in the epidermis followed by acanthosis (44, 88%) and hypergranulosis
(43, 86%) respectively.
Epidermis showed marked psoriasiform hyperpasia, focal hypergranulosis
, compact hyperkeratosis with foci of broad parakeratosis (Figure 4, 5).
Hypertrophic lichen planus also tends to have more hypergranulosis
Compact orthokeratosis, wedge-shaped hypergranulosis
, irregular acanthosis, colloid bodies, flattened rete ridges, liquefactive degeneration of basal layer, and Max Joseph's space.