hypereosinophilic syndrome


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Related to hypereosinophilic syndrome: eosinophilia

hypereosinophilic syndrome

 [hi″per-e″o-sin″o-fil´ik]
any of several diseases characterized a massive increase in the number of eosinophils in the blood and bone marrow, with eosinophilic infiltration of other organs. Symptoms vary, depending on the organ involved, and may include pruritic skin ulcers or erythroderma, endomyocarditis, lymph node or spleen enlargement, and ophthalmologic or gastrointestinal complications. Eosinophilic leukemia is a potentially fatal member of the group.

hy·per·e·o·sin·o·phil·ic syn·drome

persistent peripheral eosinophilia with eosinophilic infiltration into bone marrow, heart, and other organ systems; accompanied by nocturnal sweating, coughing, anorexia and weight loss, itching and various skin lesions, and symptoms of Löffler endocarditis.

hypereosinophilic syndrome

(hī′pər-ē′ə-sĭn′ə-fĭl′ĭk)
n.
Any of various syndromes in which the concentration of eosinophils increases in peripheral blood with later infiltration into bone marrow, heart, and other organ systems.

hypereosinophilic syndrome

A heterogeneous group of conditions characterized by persistent peripheral eosinophilia with infiltration of eosinophils in BM, heart, and other organs, which may be a form of myeloproliferative disorder–possibly eosinophilic leukemia as
1. 25% have chromosomal abnormalities–eg, aneuploidy and ↓ vitamin B12 with persistent eosinophilia–> 1500 x 109/L for > 6 months;.
2. Absence of 2º causes of eosinophilia, despite aggressive workup;.
3. Sx due to organ involvement or dysfunction Clinical Age of onset, 20–50, generalized weakness, dyspnea, cough, malaise, myalgia, anorexia, angioedema, rash, low-grade fever, night sweats, weight loss, rhinitis, and Sx of Löffler's endocarditis; eosinophils cause dysfunction in heart, BM, liver, spleen, CNS, either focal–due to emboli–or diffuse, causing altered behavior and cognition, psychosis, ataxia, spasticity, peripheral symmetrical polyneuropathy, coma, GI tract–diarrhea, abdominal pain, malabsorption, lungs–interstitial inflammation with eosinophils, and skin–nonspecific rashes; once the heart is involved–eg, endocardial fibrosis, thrombosis and restrictive cardiomyopathy, death < 1 yr Management Possibly corticosteroids.

hy·per·e·o·sin·o·phil·ic syn·drome

(hī'pĕr-ē'ō-sin-ō-fil'ik sin'drōm)
Persistent peripheral eosinophilia with later infiltration into bone marrow, heart, and other organ systems; accompanied by nocturnal sweating, coughing, anorexia and weight loss, itching, various skin lesions, and symptoms of Löffler endocarditis.

hy·per·e·o·sin·o·phil·ic syn·drome

(hī'pĕr-ē'ō-sin-ō-fil'ik sin'drōm)
Persistent peripheral eosinophilia with eosinophilic infiltration into bone marrow, heart, and other organ systems; accompanied by nocturnal sweating, coughing, and anorexia and weight loss.

hypereosinophilic syndrome

a group of disorders in humans characterized by greatly increased numbers of eosinophils in the blood, mimicking leukemia, and eosinophilic infiltration of many tissues. Eosinophilic enteritis, eosinophilic leukemia, and eosinophilic granuloma complex in cats are similar disorders.
References in periodicals archive ?
Refining the definition of hypereosinophilic syndrome.
The report assesses Hypereosinophilic Syndrome therapeutics based on drug target, mechanism of action (MoA), route of administration (RoA) and molecule type
Incidence of myeloproliferative hypereosinophilic syndrome in the United States and an estimate of all hypereosinophilic syndrome incidence.
A review of the Hypereosinophilic Syndrome products under development by companies and universities/research institutes based on information derived from company and industry-specific sources.
Idiopathic hypereosinophilic syndrome is a rare, leukoproliferative multisystem disorder characterized by sustained over production of eosinophils.
Eosinophilic leukemia: A myeloproliferative disorder distinct from the hypereosinophilic syndrome.
Here we are reporting a case of hypereosinophilic syndrome presenting as restrictive cardiomyopathy and eosinophilic gastritis, a high suspicion should be kept in mind for the above diagnosis when patient presents with hypereosinophilia.
Classification of eosinophil-associated gastroenteritis (5) Primary (mucosa, muscularis, serosal forms) Atopic Nonatopic Familial Secondary Eosinophilic disorders Hypereosinophilic syndrome Noneosinophilic disorders Celiac disease Connective tissue disease Iatrogenic Infection Inflammatory bowel disease Vasculitis (Churg-Strauss)
Classically, hypereosinophilic syndrome (HES) represented a diagnosis of exclusion for patients who met certain clinical criteria.
Abstract: Two cases of hypereosinophilic syndrome that illustrate different variants are reported.
Circulating Charcot-Leyden crystals in the hypereosinophilic syndrome.