hypereosinophilic syndrome


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Related to hypereosinophilic syndrome: eosinophilia

hypereosinophilic syndrome

 [hi″per-e″o-sin″o-fil´ik]
any of several diseases characterized a massive increase in the number of eosinophils in the blood and bone marrow, with eosinophilic infiltration of other organs. Symptoms vary, depending on the organ involved, and may include pruritic skin ulcers or erythroderma, endomyocarditis, lymph node or spleen enlargement, and ophthalmologic or gastrointestinal complications. Eosinophilic leukemia is a potentially fatal member of the group.

hy·per·e·o·sin·o·phil·ic syn·drome

persistent peripheral eosinophilia with eosinophilic infiltration into bone marrow, heart, and other organ systems; accompanied by nocturnal sweating, coughing, anorexia and weight loss, itching and various skin lesions, and symptoms of Löffler endocarditis.

hypereosinophilic syndrome

(hī′pər-ē′ə-sĭn′ə-fĭl′ĭk)
n.
Any of various syndromes in which the concentration of eosinophils increases in peripheral blood with later infiltration into bone marrow, heart, and other organ systems.

hypereosinophilic syndrome

A heterogeneous group of conditions characterized by persistent peripheral eosinophilia with infiltration of eosinophils in BM, heart, and other organs, which may be a form of myeloproliferative disorder–possibly eosinophilic leukemia as
1. 25% have chromosomal abnormalities–eg, aneuploidy and ↓ vitamin B12 with persistent eosinophilia–> 1500 x 109/L for > 6 months;.
2. Absence of 2º causes of eosinophilia, despite aggressive workup;.
3. Sx due to organ involvement or dysfunction Clinical Age of onset, 20–50, generalized weakness, dyspnea, cough, malaise, myalgia, anorexia, angioedema, rash, low-grade fever, night sweats, weight loss, rhinitis, and Sx of Löffler's endocarditis; eosinophils cause dysfunction in heart, BM, liver, spleen, CNS, either focal–due to emboli–or diffuse, causing altered behavior and cognition, psychosis, ataxia, spasticity, peripheral symmetrical polyneuropathy, coma, GI tract–diarrhea, abdominal pain, malabsorption, lungs–interstitial inflammation with eosinophils, and skin–nonspecific rashes; once the heart is involved–eg, endocardial fibrosis, thrombosis and restrictive cardiomyopathy, death < 1 yr Management Possibly corticosteroids.

hy·per·e·o·sin·o·phil·ic syn·drome

(hī'pĕr-ē'ō-sin-ō-fil'ik sin'drōm)
Persistent peripheral eosinophilia with later infiltration into bone marrow, heart, and other organ systems; accompanied by nocturnal sweating, coughing, anorexia and weight loss, itching, various skin lesions, and symptoms of Löffler endocarditis.

hy·per·e·o·sin·o·phil·ic syn·drome

(hī'pĕr-ē'ō-sin-ō-fil'ik sin'drōm)
Persistent peripheral eosinophilia with eosinophilic infiltration into bone marrow, heart, and other organ systems; accompanied by nocturnal sweating, coughing, and anorexia and weight loss.

hypereosinophilic syndrome

a group of disorders in humans characterized by greatly increased numbers of eosinophils in the blood, mimicking leukemia, and eosinophilic infiltration of many tissues. Eosinophilic enteritis, eosinophilic leukemia, and eosinophilic granuloma complex in cats are similar disorders.
References in periodicals archive ?
Cerebral arteriolar thromboembolism in idiopathic hypereosinophilic syndrome.
Thrombotic microangiopathy associated with the hypereosinophilic syndrome.
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.
Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness.
Coverage of the Hypereosinophilic Syndrome pipeline on the basis of route of administration and molecule type.
Identify and understand important and diverse types of therapeutics under development for Hypereosinophilic Syndrome.
The cardiovascular manifestations of the hypereosinophilic syndrome.
Interferon-alpha treatment of six patients with the idiopathic hypereosinophilic syndrome.
A clinicopathologic correlation of ideopathic hypereosinophilic syndrome.
Hypereosinophilic syndrome in childhood: Trisomy 8 and transformation to mixed acute leukemia.
It is now important to separate idiopathic hypereosinophilic syndrome from the chronic myeloproliferative disorders, which may present as hypereosinophilic syndrome but involve a persistent stem cell disorder of the bone marrow.
Since its discovery as treatment for chronic myelogenous leukemia (CML), this molecularly-targeted drug has fueled intense interest in research, leading to its use in the treatment of gastrointestinal stromal tumors, chronic myelomonocytic leukemia and now hypereosinophilic syndrome.