One reported karyotype of adenosarcoma with sarcomatous overgrowth revealed a hyperdiploid
karyotype with multiple structural and numerical abnormalities involving chromosomes 2, 8, 10, 13, 19, and 21.
sup] and is over-expressed in human T-cell acute and hyperdiploid
precursor B-cell acute lymphoblastic lymphoma, which is involved in leukemia initiation.
patients with a chromosomal number of more than 50 have a better prognosis; this is more frequent in children than in adults.
Evidence for a single-step mechanism in the origin of hyperdiploid
childhood acute lymphoblastic leukemia.
karyotype was seen with chromosome 13 aberrations in 10 patients, with both chromosome 13 aberrations and P53 deletion in 2 patients and with P53 deletion in 1 patient.
Number of diploid chromosomes : As the chromosomes were small and difficult to differentiate, we sampled 50 cells and only calculated the numbers of hypodiploid, diploid and hyperdiploid
karyotypes, often with gains in the region containing the JAK2 gene on chromosome 9p, have been noted.
Two studies found that aneuploidy increased in normal human lung fibroblasts after a 30 h exposure to soluble chromate with a specific increase in hypodiploid cells but no increase in hyperdiploid
(47-50) acute lymphoblastic leukemia in children.
In contrast, hyperdiploid
cells in ALL have a better prognosis (11,13).
The percentage of hyperdiploid
cells increased from second passage onward in calli grown on 2,4 D/Kinetin, as evidenced by chromosome number and in situ nuclear DNA content (Table II).
They base this determination on the technology's ability to uncover any exfoliated epithelial cells with true aneuploidy or abnormal hyperdiploid
(S + G2M) DNA values > 15 per cent).