hypercortisolism


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Related to hypercortisolism: Addison's disease, hyperaldosteronism, Cushing syndrome, Hypocortisolism

hypercortisolism

(hī″pĕr-kort″ĭ-sol″izm) [ hyper- + cortisol + -ism]
Excess levels of cortisol in the blood, caused by administered corticosteroid drugs, an adrenocorticotropic hormone–secreting tumor, or adrenal overproduction of cortisol.

hypercortisolism (Cushing syndrome),

n a genetic or acquired condition resulting in elevated levels of glucocorticoids, often as a result of tumors in adrenal or pituitary glands. Leads to significant weight gain, particularly on the back (causing a “buffalo hump”) and face. More commonly caused by steroid use/abuse, in which case it is called Cushing syndrome medicamentosus.

hypercortisolism

a state of excess production of cortisol; cushing's syndrome.
References in periodicals archive ?
As James Findling (11) once said, "if you have never missed the diagnosis of ACTH-dependent Cushing syndrome, and you have never been fooled attempting to establish its cause, you should refer your patients with suspected hypercortisolism to somebody who has" (personal communication).
Hypercortisolism results in multiple medical problems, including hypertension, obesity, osteoporosis, fractures, impaired wound healing, infectious diseases, glucose intolerance, and psychosis.
Research by Gold and George Chrousos of the National Institute of Child Health and Human Development--a coauthor of the NEJM paper with Gold and Frederic Goodwin, director of the Alcohol, Drug Abuse and Mental Health Administration -- suggests this hypercortisolism is indirectly caused by an overproduction of CRH and therefore by an activation of the stress circuits in the brain and body.
In our series, 1 patient with myelolipoma had central obesity and hypercortisolism.
and the EU as a once-daily oral medication for the treatment of hyperglycemia secondary to hypercortisolism in adults suffering from endogenous Cushing's syndrome, who have type II diabetes or glucose intolerance.
However, over the course of the next 2-3 weeks ACTH and cortisol returned to pre-procedure levels and the patient once again suffered from the effects of hypercortisolism.
Other endocrine disorders that can contribute to hypertriglyceridemia are acromegaly, hypothyroidism, and hypercortisolism.
Most studies report that conditions of FM, chronic pain, and fatigue as well as atypical depression (depression characterized by excess sleeping, increased appetite, and profound fatigue) are characterized not by hypercortisolism, but instead decreased cortisol production and release.
Endogenous hypercortisolism also has been associated with excess levels of homocysteine, which might contribute to the prothrombotic state in such patients and their future risks of cardiovascular disease and/or venous thrombosis (13).
The dexamethasone-suppressed corticotropin-releasing hormone stimulation (LDDST-CRH) [1] test was initially proposed to be more accurate in confirming hypercortisolism than the standard low-dose dexamethasone-suppression test (LDDST) for the diagnosis of Cushing syndrome (2).
Pseudo-Cushing Syndrome: Medical condition in which patients exhibit the signs and symptoms of hypercortisolism but which is not caused by a problem with the hypothalamic--pituitary--adrenal axis.