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hypercortisolism |
Also found in: Wikipedia, Hutchinson | 0.06 sec. |
hypercortisolism (Cushing syndrome), n a genetic or acquired condition resulting in elevated levels of glucocorticoids, often as a result of tumors in adrenal or pituitary glands. Leads to significant weight gain, particularly on the back (causing a “buffalo hump”) and face. More commonly caused by steroid use/abuse, in which case it is called Cushing syndrome medicamentosus. hypercortisolism a state of excess production of cortisol; cushing's syndrome. |
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For this reason, the disorder is sometimes called hypercortisolism. Research by Gold and George Chrousos of the National Institute of Child Health and Human Development--a coauthor of the NEJM paper with Gold and Frederic Goodwin, director of the Alcohol, Drug Abuse and Mental Health Administration -- suggests this hypercortisolism is indirectly caused by an overproduction of CRH and therefore by an activation of the stress circuits in the brain and body. |
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hypercortisolism