hypercalcemia of malignancy

hypercalcemia /hy·per·cal·ce·mia/ (-kal-se´me-ah) an excess of calcium in the blood.

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idiopathic hypercalcemia  a condition of infants, associated with vitamin D intoxication, characterized by elevated serum calcium levels, increased density of the skeleton, mental deterioration, and nephrocalcinosis.

hypercalcemia of malignancy  abnormal elevation of serum calcium associated with malignant tumors, resulting from osteolysis caused by bone metastases or by the action of circulating cytokines released from tumor cells.

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hypercalcemia of malignancy,

an abnormal elevation of serum calcium associated with malignant tumors, resulting from osteolysis caused by bone metastases or by the action of circulating osteoclast-activating factors released from distant tumor cells (known as humoral hypercalcemia of malignancy).

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hypercalcemia of malignancy

A clinical complex, 50% of which results from hypersecretion of parathyroid hormone-related protein–PTHRP, aka parathyroid hormone-related peptide; HCM may result from either direct replacement–eg, in lympho- and myeloproliferative malignancies–eg, leukemia, adult T cell lymphoma, Burkitt's lymphoma, lymphosarcoma, myeloma or solid tumors–eg, CA of breast, lung, pancreas, or due to factors; normal subjects have low–<2.0 pmol/L levels of PTHRP, while those with HCM may have plasma levels > 20.9 pmol/L; hypercalcemia may be moderate 10.8-12 mg/dL; or severe >12 mg/dL; HCM is uncommon– ± 1% and occurs in Pts with more advanced disease, distant metastases, and poor prognoses Diagnosis RIA Treatment HCM may respond to bleomycin