hyperbradykininism

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hyperbradykininism /hy·per·brady·ki·nin·ism/ (-brad″ĭ-ki´nin-izm) a syndrome of high plasma bradykinin associated with a fall in systolic blood pressure on standing, increased diastolic pressure and heart rate, and ecchymoses of lower limbs.

bradykinin [brad″e-ki´nin]

a nonapeptide kinin formed from a plasma protein, high-molecular-weight (HMW) kininogen by the action of kallikrein; it is a very powerful vasodilator that increases capillary permeability and, in addition, constricts smooth muscle and stimulates pain receptors.

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