hyperalgesic


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hy·per·al·ge·sic

, hyperalgetic (hī'pĕr-al-jē'sik, -jet'ik),
Relating to hyperalgesia.

hy·per·al·ge·sic

, hyperalgetic (hī'pĕr-al-jē'sik, -jet'ik)
Relating to hyperalgesia.
References in periodicals archive ?
Morphine hyperalgesic effects on developmental changes in thermal nociception and respiration in domestic fowl (Gallus gallus).
In studies using experimental pain induction, subjects on MMT are hyperalgesic and have a much lower tolerance to the cold pressor test compared with control groups (47-49).
These findings indicate that doses of morphine far below those currently required for clinical treatment of pain may become effective when opioid hyperalgesic effects are blocked by co-administration of appropriately low doses of opioid antagonists (74).
The symposium will review certain cellular, preclinical and clinical aspects of low-dose opioid antagonist technology and is entitled "Selective Blockade of Excitatory Opioid Hyperalgesic Functions Enhances Morphine's Analgesic Potency and Attenuates Opioid Tolerance/Dependence Liability.
Hyperalgesic priming depends on the epsilon isoform of protein kinase C (PKC epsilon) and a switch in intracellular signaling pathways that mediate cytokine-induced nociceptor hyperexcitability.
It is known that local administration of low doses of opiates into inflamed, hyperalgesic tissue can result in significantly reduced pain sensitivity without side effects, a phenomenon known as peripheral opiate antihyperalgesia.
Remifentanil has the potential to be associated with difficult-to-control pain in the postoperative period, which may reflect a hyperalgesic state.
Treatment of mice with 50 and 100 mg/kg of bergenin inhibited both the early and late phases in a formalin test, inhibited mechanical hyperalgesia, edema, and paw production of hyperalgesic cytokines (TNF-[alpha] and IL-1 [beta]) induced by complete Freund's adjuvant (De Oliveira et al.
The tantalising possibility exists that exposure to buprenorphine, possibly in quite low doses, in combination with other opioid and analgesic drugs, will improve pain relief, by reducing putative hyperalgesic and pronociceptive effects.