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hydroxyproline |
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hydroxyproline /hy·droxy·pro·line/ (-pro´lēn) a hydroxylated form of proline, occurring in collagen and other connective tissue proteins.
hydroxyproline [-prō′lēn] an amino acid whose level in the urine is elevated in diseases of the bone and certain genetic disorders, such as Marfan's syndrome. Its normal accumulation in urine after a 24-hour collection is 10 to 75 mg. hydroxyproline Hyp; an amino acid derived from proline. hydroxyproline Biochemistry A hydroxylated amino acid which is most concentrated in collagen ↑ in urine Indicates ↑ turnover of bone matrix, often caused by osteoporosis ↓ in Malnutrition, ↑ by acromegaly, acute
osteomyelitis, burns, congenital hyperphosphatasia, fibrous dysplasia, healing fractures, hyperparathyroidism, hyperthyroidism, Marfan syndrome, osteomalacia, Paget's disease of bone, parathyroid adenoma, rickets, bone tumors How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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A urine hydroxyproline assay also yielded a normal result of 2. Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. In the biochemical assays, the total collagen was quantified indirectly by measuring the hydroxyproline concentration in samples of the Achilles tendons using a protocol previously published by these authors. |
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