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hydroxyproline

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hydroxyproline /hy·droxy·pro·line/ (-pro´lēn) a hydroxylated form of proline, occurring in collagen and other connective tissue proteins.
hy·drox·y·pro·line (h-drks-prln)
n.
An amino acid produced during the hydrolysis of collagen.

hydroxyproline
[-prō′lēn]
an amino acid whose level in the urine is elevated in diseases of the bone and certain genetic disorders, such as Marfan's syndrome. Its normal accumulation in urine after a 24-hour collection is 10 to 75 mg.

hydroxyproline
Hyp; an amino acid derived from proline.

hydroxyproline
Biochemistry A hydroxylated amino acid which is most concentrated in collagen ↑ in urine Indicates ↑ turnover of bone matrix, often caused by osteoporosis ↓ in Malnutrition, ↑ by acromegaly, acute osteomyelitis, burns, congenital hyperphosphatasia, fibrous dysplasia, healing fractures, hyperparathyroidism, hyperthyroidism, Marfan syndrome, osteomalacia, Paget's disease of bone, parathyroid adenoma, rickets, bone tumors


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A urine hydroxyproline assay also yielded a normal result of 2.
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
In the biochemical assays, the total collagen was quantified indirectly by measuring the hydroxyproline concentration in samples of the Achilles tendons using a protocol previously published by these authors.
 
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