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hydroxylation
(redirected from hydroxylate)

   Also found in: Dictionary/thesaurus, Wikipedia 0.01 sec.
hydroxylation
addition of −OH groups to a molecule.


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The lack of enzyme predisposed her to the inability to hydroxylate methadone, amitriptyline, and nortriptyline, resulting in an overall accumulation and drug toxicity.
Since thyroxine is needed to hydroxylate cortisone--thereby enabling the kidney to convert it to a glucronide and excrete it--the serum level of cortisone may fall precipitously with the institution of thyroid therapy, the "asleep" adrenals failing to respond.
Although there is no recommended dietary intake (RDI) for this vitamin, it is explained in the background paper that vitamin D supplements may be required for elderly people who are immobile or infirmed and confined indoors; and in patients with chronic renal failure who are unable to hydroxylate the precursor (25 hydroxyvitamin D3) to the active form (1,25 dihydroxyvitamin D3), a process which normally occurs in the kidneys.
 
 
 
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