hydroxylase /hy·drox·y·lase/ (hi-drok´sĭ-lās) any of a group of enzymes that catalyze the formation of a hydroxyl group on a substrate by incorporation of one atom (monooxygenases) or two atoms (dioxygenases) of oxygen from O2.
11β-hydroxylase an enzyme that catalyzes the hydroxylation of steroids at the 11 position, a step in the synthesis of steroid hormones; deficiency causes a form of congenital adrenal hyperplasia.
17α-hydroxylase an enzyme that catalyzes the oxidation of steroids at the 17 position, steps in the synthesis of steroid hormones; deficiency causes a form of congenital adrenal hyperplasia and if it occurs during gestation can cause male pseudohermaphroditism.
18-hydroxylase an enzyme that catalyzes several steps in the biosynthesis of aldosterone from corticosteroids; deficiency causes salt wasting.
21-hydroxylase an enzyme that catalyzes the hydroxylation of steroids at the 21 position, a step in the synthesis of steroid hormones; deficiency impairs the ability to produce all glucocorticoids and causes a form of congenital adrenal hyperplasia.
hy·drox·yl·ase (h -dr k s -l s , -lz)n. Any of various enzymes that catalyze the formation of hydroxyl groups by oxidation of the substrate. |
hydroxylase
any enzyme that brings about the coupled oxidation of two donors, with incorporation of oxygen into one of them.
21-hydroxylase
a partial deficiency of the enzyme, in Pomeranian dogs, is thought to cause a dermatosis; histopathological lesions are of cutaneous atrophy; clinical signs include bilateral alopecia of the trunk, caudal thighs, ventral neck.
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