A chemical compound, also called vitamin B12a, which is the immediate precursor to cyanocobalamin (vitamin B12) in the body and that has also been investigated as an antidote in cyanide poisoning, although it is not currently approved for such use in the U.S.
See also: amyl nitrite, sodium nitrite, sodium thiosulfate
Synonym(s): hydroxocobalamin.

hydroxocobalamin, hydroxycobalamin

an analog of cyanocobalamin (vitamin B12) having exceptionally long-acting hematopoietic activity. Called also vitamin B12b.
References in periodicals archive ?
Hydrogen peroxide was rapidly produced by combination of 25 [micro]M hydroxycobalamin and 500 [micro]M ascorbic acid added to cell-free culture medium (containing nutrients including an iron salt).
A similar accumulation of hydrogen peroxide occurred when hydroxycobalamin and ascorbic acid were added to human epidermoid larynx carcinoma cells (HEp-2).
A) Intramuscular hydroxycobalamin 1,000-mcg load daily for 1 week, then 1,000 meg monthly.
Contract awarded for code: 10413 cianocabalamina, pyridoxine hydrochloride clohidrato thiamine hydroxycobalamin 25,000 injectable solution.
3]- [less than or equal to]15 mmol/l Empirical Carnitine 100 mg/kg/day Some disorders may administration of IV/O Hydroxycobalamin respond dramatically metabolic (vit [B.
Previous studies have shown that some patients given cyano--or hydroxycobalamin have developed antibodies to TC, leading to markedly increased serum TC and vitamin [B.
Antibody to transcobalamin II and B12 binding capacity in patients treated with hydroxycobalamin.
After supplementation with 3 mg of hydroxycobalamin IM twice per week with 5 mg of folinic acid orally daily, she was transformed.
12] (methylcobalamin, hydroxycobalamin, and adenosylcobalamin) into the stable cyanocobalamin form.
The Banbury researchers treated participants with B12 deficiency (below 133 pmol/l) with hydroxycobalamin (1000 [micro]g intramuscularly/month) for three months.
Defects in cobalamin metabolism (CblC, D, E, G) [2, 13] may be difficult to diagnose unless tHcy is measured; diagnosis is important, as the response to hydroxycobalamin therapy is good.
I still, after 36 years, love our adrenal complex shot with hydroxycobalamin and folic acid in time-released sesame oil.