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an analogue of cyanocobalamin (vitamin B12) having exceptionally long-acting hematopoietic activity; used in the treatment of pernicious anemia and other macrocytic anemias.


Vitamin B12b, differing from cyanocobalamin (vitamin B12) in the presence of a hydroxyl ion in place of the cyanide ion at the sixth coordinate position on the cobalt atom.
See also: vitamin B12.
Synonym(s): hydroxocobemine


/hy·droxo·co·bal·a·min/ (hi-drok″so-ko-bal´ah-min) a hydroxyl-substituted cobalamin derivative, the naturally occurring form of vitamin B12 and sometimes used as a source of that vitamin.


A chemical compound, also called vitamin B12a, which is the immediate precursor to cyanocobalamin (vitamin B12) in the body and that has also been investigated as an antidote in cyanide poisoning, although it is not currently approved for such use in the U.S.
See also: amyl nitrite, sodium nitrite, sodium thiosulfate
Synonym(s): hydroxocobalamin.


Vitamin B12. This is the specific treatment for PERNICIOUS ANAEMIA and is highly effective unless neurological damage has already occurred. The drug is on the WHO official list. Brand names are Cobalin-H and Neo-Cytamen.

hydroxocobalamin, hydroxycobalamin

an analog of cyanocobalamin (vitamin B12) having exceptionally long-acting hematopoietic activity. Called also vitamin B12b.
References in periodicals archive ?
5 ml of 10% calcium gluconate, 1,000 [micro]g of hydroxocobalamin, 100 mg of pyridoxine, 250 mg of dexpanthenol, and 1 ml of B complex 100.
12] deficiency, guidelines from the National Health Service in the United Kingdom and the British Society for Haematology recommend treatment with IM hydroxocobalamin, 1,000 IU, 3 times weekly, for 2 weeks.
Six medicines without licensing by Anvisa were incorporated in the period: Biotin (biotidinase deficiency), injectable doxycycline and chloramphenicol oral suspension (spotted fever), hydroxyurea 100mg tablet (sickle cell disease), hydrocortisone cypionate (congenital adrenal hyperplasia), and hydroxocobalamin hydrochloride (cyanide poisoning).
Prevention of hydrogen sulfide (H2S)-induced mouse lethality and cytotoxicity by hydroxocobalamin (vitamin B(12a)).
In this case, the child responded biochemically to hydroxocobalamin (1 mg daily) in combination with protein restriction with no further complications, remaining asymptomatic.
Tenders are invited for to provide compounded hydroxocobalamin to ldh clinics statewide as indicated in the attachments from date of award through july 31, 2017.
To investigate the effects of NRG-1 on neuronal Cbl mechanism, especially the effects on synthesis of bioactive Cbl species, we utilized a novel HPLC/electrochemical detection-based assay which is able to sensitively and accurately quantify six naturally occurring Cbl species in human cultured neuronal SH-SY5Y cells, including hydroxocobalamin (OHCbl), GSCbl, sulfitocobalamin (S[O.
Absorption of cyanocobalamin, coenzyme B 12, methylcobalamin, and hydroxocobalamin at different dose levels.
The effects of these agents on human pregnancy also are unknown, as are the effects of high-dose hydroxocobalamin, an analogue of vitamin [B.
Initial management should include correction of acidosis, inotropic support, and antidotal therapy with prepackaged cyanide antidote kits (inhaled amyl nitrite ampoule initially or intravenous sodium nitrate, 10 ml; followed by intravenous 25% sodium thiosulfate, 50 ml) or a combination of sodium thiosulfate and hydroxocobalamin (5g intravenously over 15 min.
While there is no antidote for hydrogen disulfide poisoning, cyanide poisoning can be treated with hydroxocobalamin.
The new presentation contains the initial antidote dose of 5 g hydroxocobalamin in a single vial.