Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid
, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).
Briefly, it consists of reacting the ester with hydroxylamine to produce a hydroxamic acid
, which can be treated with a Iron(III) solution, producing a chromophore if esters are present with an absorption maxima around 505-520nm.
Hydroxamic acids affecting barley yellow dwarf virus transmission by the aphid (Rhopalosiphum padi).
Biological formation and pharmacological, toxicological, and pathological properties of hydroxylamines and hydroxamic acids.
The same is true for the hydroxamic acids, the quinones, and the
Presence of a hydroxamic acid glucoside in wheat phloem sap, and
The organic thermochemistry of hydroxylamines, oximes, hydroxamic acids and their derivatives
NMR spectra of hydroxylamines, oximes and hydroxamic acids
Poster #357 -- "Preclinical Analysis of N-Alkyl Urea Hydroxamic Acid
Peptide Deformylase Inhibitors;" Zhengyu Yuan, Ph.
The field of inhibiting HDACs has emerged as a novel human anticancer strategy and MethylGene has developed multiple series of small molecule inhibitors of HDACs, including sulfonamide hydroxamic acids
and anilides, as described in the Company's recently accepted chemistry paper entitled "Development of potential antitumor agents.
He presented a talk titled Sulfonamide Hydroxamic Acids
, A Novel Class of Histone Deacetylase Inhibitors, are Antiproliferative Against Human Cancer Cells.
Therefore, the carboxylic acid moieties were partially converted to hydroxamic acid
moieties by reacting the carboxylic acid groups with hydroxylamine (ref.