hydroxamic acid


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hydroxamic acid

an inhibitor of urease and a chelating agent. See also acetohydroxamic acid.
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Table 1: Types of epigenetic drugs: Drugs Class 5-aza-cytidine (azacitidine), Nucleoside DNMTIs 5-aza-2-deoxycytidine (decitabine), 5-fluoro-2-deoxycytidine, Zebularine RG108 Non-Nucleoside DNMTIs MG98 Antisense Oligonucleotides Table 2: HDAC inhibitors: Drugs Class Valproic acid, Aliphatic acids Sodium phenylbutyrate, Pivaloyloxymethyl butyrate, Vorinostat Romidepsin Cyclic peptides Belinostat, Hydroxamic acids Panobinostat Entinostat, Benzamides Mocetinostat
The mechanism of the anti-tumor activity of the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA).
Zn(II)-dependent histone deacetylase inhibitors: suberoylanilide hydroxamic acid and trichostatin A.
Histone deacetylase inhibitors: development of suberoylanilide hydroxamic acid (SAHA) for the treatment of cancers.
He also holds a patient on hydroxamic acid crown ethers.
Suberoylanilide hydroxamic acid (SOHA) is an agent developed at Sloan-Kettering, where it's under study for treatment of several different types of advanced malignancies.
Scientists at the Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City, led by MSKCC president emeritus Paul Marks, have discovered that the HDAC inhibitor suberoylanilide hydroxamic acid (SAHA) causes cancer cells to stop growing and die.
Presence of a hydroxamic acid glucoside in wheat phloem sap, and
Analogues of the cyclic hydroxamic acid 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3-one: Decomposition to benzoxazolinones and reaction with b-mercaptoethanol.
and British colleagues added an HDAC inhibitor called suberoylanilide hydroxamic acid to the drinking water of young mice genetically engineered to make mutated huntingtin protein.