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1. Any enzyme that removes a hydride ion (or H:-) from NADH (or NADPH). Synonym(s): hydrogenlyase
2. The enzyme that catalyzes the reaction of 2H+ with ferricytochrome or ferredoxin to generate H2.
hydrogenlyase(1) EC 220.127.116.11 (transferred to ferredoxin hydrogenase, EC 18.104.22.168).
(2) Any enzyme that removes H+ from NADH or adds H+ to ferricytochrome or ferredoxin