hydrocortisone


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hydrocortisone

 [hi″dro-kor´tĭ-sōn]
the pharmaceutical term for cortisol, the principal glucocorticoid secreted by the adrenal gland; the base and its salts, including h. acetate, h. butyrate, h. cypionate, h. probutate, h. sodium phosphate, h. sodium succinate, and h. valerate, are used in replacement therapy for adrenocortical insufficiency and as antiinflammatory and immunosuppressant agents in the treatment of a wide variety of disorders.

hy·dro·cor·ti·sone

(hī'drō-kōr'ti-sōn),
The principal glucocorticoid produced by the adrenal cortex. Although synthetic products used medicinally are usually known by this name, the natural hormone is more often called cortisol. See: cortisol.

hydrocortisone

/hy·dro·cor·ti·sone/ (-kor´tĭ-sōn) the name given to natural or synthetic cortisol when it is used as a pharmaceutical. The base and its salts, including h. acetate, h. butyrate, h. cypionate, h. probutate, h. sodium phosphate, h. sodium succinate, and h. valerate are used as replacement therapy in adrenocortical insufficiency and as antiinflammatory and immunosuppressant agents in the treatment of a wide variety of disorders.

hydrocortisone

(hī′drə-kôr′tĭ-sōn′, -zōn′)
n.
1. The steroid hormone cortisol.
2. A preparation of this hormone obtained from natural sources or produced synthetically and used to treat inflammatory and allergic conditions and adrenal failure.

hydrocortisone

[-kôr′tisōn]
a topical corticosteroid.
indication It is prescribed for the topical treatment of skin inflammation.
contraindications Viral and fungal diseases of the skin that occur where circulation is impaired or known hypersensitivity to steroids prohibits its use.
adverse effects Among the more serious adverse effects are various systemic side effects that may result from prolonged or excessive use. Local irritation of the skin may occur.

hydrocortisone, hydrocortisone acetate, hydrocortisone cyclopentylpropionate

See cortisol.

hydrocortisone

Cortisol The principal corticosteroid secreted by the adrenal cortex, which has mineralocorticoid activity, and relieves Sx of certain hormone deficiencies, and is immunosuppressive

hy·dro·cor·ti·sone

(hī'drō-kōr'ti-sōn)
A steroid hormone secreted by the cortex of the suprarenal gland and the most potent of the naturally occurring glucocorticoids in humans.
Synonym(s): cortisol.

hydrocortisone

A natural steroid hormone derived from the outer layer (cortex) of the adrenal gland. The drug CORTISONE is converted into hydrocortisone in the liver. Hydrocortisone has anti-inflammatory and sodium-retaining properties. It is widely used as a mild CORTICOSTEROID drug mainly for skin disorders. The drug is on the WHO official list. Brand names are Colifoam, Corlan, Dioderm, Efcortelan, Efcortesol, Hydrocortistab, Hydrocortone, Midison Lipocream. The drug is also formulated, for external use, with a variety of other drugs such as allantoin, antibiotics, azole antifungal drugs, coal tar extracts, crotamiton (anti-itch drug), hydrating agents, local anaesthetics, zinc oxide, etc. At least 40 preparations containing hydrocortisone are available on the UK drug market.

cortisol

or

hydrocortisone

an adrenocortical steroid with effects similar to CORTISONE.

Hydrocortisone

A steroid hormone produced by the adrenal glands that provides resistance to stress.

glucocorticoids

the group of corticosteroid hormones (mainly cortisol syn hydrocortisone, of which cortisone is the precursor) produced by the adrenal cortex, under the control of adrenocorticotrophic hormone (ACTH) from the anterior pituitary. Their major actions on nutrient metabolism have the net effect of promoting glucose and free fatty acid availability as fuels. Also vital for normal cellular processes as diverse, for example, as excitation-contraction coupling and the health of connective tissues. Synthetic steroids such as prednisolone and dexamethasone have similar actions and are used in the treatment of, for example, asthma and rheumatic conditions. Banned in sport due to their powerful anti-inflammatory action and effect of producing euphoria and masking pain. (Not to be confused with anabolic steroids). See also adrenal glands, hormones; Table 1.
Table 1: Hormones
Site of productionName of hormoneMain targetsInvolved in regulating:Secretion controlled by:
HypothalamusReleasing and inhibiting hormonesAnterior pituitary (via local blood vessels)Secretion of anterior pituitary hormonesOther brain regions; feedback re regulated hormones and their actions
Neurohormones released from posterior pituitary:
OxytocinUterus, breastsLabour and lactationAfferent information from target organs
Antidiuretic hormone (ADH, vasopressin)KidneysWater loss: ECF volume and osmolalityHypothalamic osmoreceptors
Anterior pituitary(Human) growth hormone (H)GHMost cellsGrowth and metabolismHypothalamic releasing and inhibiting hormones via local blood vessels
ProlactinBreastsMilk production
Trophic hormones:
Thyroid-stimulating (TSH)Thyroid glandThyroid secretions
GonadotrophinsOvary or testisGerm cell maturation and hormone secretions
Adrenocorticotrophic (ACTH)Adrenal cortexCortisol secretion
Pineal bodyMelatoninWidespread, including brain, thymus, etc.
  • Sleep/wake cycle
  • Antioxidant
  • Immune system
Hypothalamus; varying light input from retina
Thyroid
  • Thyroxine
  • Triiodothyronine
  • Calcitonin
  • Most cells
  • Bone, kidneys, gut
  • Cellular oxidative metabolism
  • Decreases ECF [Ca2+]
  • TSH from anterior pituitary. Negative feedback from blood hormone concentration
  • ECF [Ca2+]
ParathyroidsParathormoneBone, kidneys, gut
  • Calcium and phosphorus absorption, secretion and turnover in bone.
  • Increases ECF [Ca2+]
ECF [Ca2+]
Adrenal: Cortex
  • Cortisol
  • Aldosterone
  • Androgens
  • Most cells
  • Kidneys
  • Gonads & other tissues
  • Metabolism
  • Response to stress
  • Na and K balance
  • Sex characteristics and reproductive function
  • ACTH from anterior pituitary
  • ECF [Na+] [K+]
  • Renin-angiotensin
  • ACTH
Medulla
  • Adrenaline
  • Noradrenaline
Heart, smooth muscle, glandsCardiovascular and metabolic adjustments to activity and stressSympathetic nervous system
Atrial wallAtrial natriuretic hormoneKidneysBlood volume; increases sodium (therefore also water) loss in urineStretch of atrial wall by venous pressure
Gonads: TestisAndrogens (mainly testosterone)Genitalia and other tissuesReproductive function and sex characteristicsAnterior pituitary gonadotrophins
Ovary
  • Oestrogens
  • Progesterone
Uterus, breasts and other tissuesMenstrual cycle, pregnancy, lactation
Pancreas
  • Insulin, glucagon
  • Somatostatin
  • Most cells
  • Other secretory cells in the pancreas
Blood levels, storage and cellular uptake of nutrients, notably glucose, but also proteins and fatsBlood levels of nutrients; autonomic nervous system; other gastrointesinal hormones
Alimentary tract
StomachGastrinGastric acid-secreting cellsGastrointestinal functions: motility, digestive juices and other secretionsLocal chemical and mechanical factors in the alimentary tract
Small intestine
  • Secretin
  • Cholecystokinin- pancreozymin (CCK-PZ)
  • Somatostatin, motilin
  • Other peptide hormones including vasoactive intestinal peptide (VIP)
  • Widespread on
  • GI tract
Several GI functions including bile flow, pancreatic enzyme and exocrine secretionsIngestion of food, distension of GI tract

hydrocortisone

; cortisol potent, naturally occurring glucocorticoids that suppress inflammation (e.g. topical ointment; intra-articular or enthesis injection)

hy·dro·cor·ti·sone

(hī'drō-kōr'ti-sōn)
Principal glucocorticoid produced by the cortex of the suprarenal gland. Although synthetic products used medicinally are usually known by this name, the natural hormone is more often called cortisol (q.v.).

hydrocortisone (hī´drōkôr´tisōn),

n (cortisol), a glucocorticosteroid secreted by the adrenal cortex in response to stimulation by ACTH. Hydrocortisone is antianabolic, stim-ulates gluconeogenesis, and probably acts on some cellular system in response to a need for adaptation to change (stress).
hydrocortisone acetate/hydrocortisone sodium phosphate/hydrocortisone sodium succinat,
n brand names: Cortef, Cortifoam, Cortenema;
drug class: corticosteroid;
action: decreases inflammation by suppression of macrophage and leukocyte migration; reduces capillary permeability and inhibits lysosomal enzymes;
uses: severe inflammation, shock, adrenal insufficiency, ulcerative colitis, collagen disorders.
hydrocortisone acetate/hydrocortisone valerate,
n brand names: Acticort, Cortaid, Cort-Dome, Dermicort;
drug class: topical corticosteroid;
action: interacts with steroid cytoplasmic receptors to induce antiinflammatory effects; possesses antipruritic, antiinflammatory actions;
uses: psoriasis, eczema, contact dermatitis, pruritus.

hydrocortisone

the pharmaceutical term for cortisol, the principal glucocorticoid secreted by the adrenal gland; it is used in the treatment of inflammations, allergies, pruritus, collagen diseases, adrenocortical insufficiency, and certain neoplasms. The soluble salts, sodium succinate and sodium phosphate, are used intravenously in the treatment of shock.
References in periodicals archive ?
FixMySkin is a 1% hydrocortisone balm widely tested and FDA approved for psoriasis, dry skin, eczema, dry/accutane lips, seborrheic dermatitis, bug bites and many other irritating skin conditions.
The programme will, for the first time, create a regulatory-approved paediatric version of hydrocortisone.
Plenadren is taken orally as a single dose in the morning and has been designed to provide a dual release pattern of hydrocortisone.
Based on previous results, the scientists assumed that only the combination of yohimbine and hydrocortisone attenuates goal-directed behaviour.
We conclude, as we hypothesized with our previously proposed algorithm (4), that contamination of saliva samples with topical hydrocortisone should be considered when LNSC results obtained by immunoassay are markedly increased, particularly when they are out of proportion with respect to other biochemical test results or clinical findings.
In conclusion, our study provides additional evidence that short-term treatment with neomycin/polymyxin B/ hydrocortisone otic drops is safe in humans.
The study of hydrocortisone was an attempt to intervene on abnormalities in the HPA axis that were thought to lead to PTSD.
Because hydrocortisone therapy did not lead to better outcomes in patients with septic shock, it is not recommended that it be used as general adjuvant therapy for this condition.
The hydrocortisone cream could be used once in a blue moon for an unusually bad flare up.
The findings of this observational study led to the launch earlier this year of an ongoing, multicenter, European randomized trial with a factorial design that is looking at the benefits and risks of combination steroid therapy, compared with hydrocortisone alone, Dr.
In a poster entitled, 'Intercurrent Illness Dose Regimen in Adrenal Insufficiency with a Dual-Release Hydrocortisone Formulation Derived from Population Pharmacokinetic Modeling' (#P50), additional data were presented on the use of Plenadren during intercurrent illness such as low grade infection or fever, and physical stress situations.

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