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hydralazine

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hydralazine /hy·dral·a·zine/ (hi-dral´ah-zēn) a peripheral vasodilator used in the form of the hydrochloride salt as an antihypertensive.
hy·dral·a·zine (h-drl-zn)
n.
A crystalline compound whose hydrochloride form is used in the treatment of hypertension.
hydralazine
an antihypertensive and vasodilator drug that relaxes arteriolar smooth muscle by direct action. It is used as the hydrochloride in peripheral vascular disease, thrombophlebitis and congestive heart failure.
hydralazine
Therapeutics A vasodilator which, with isosorbide dinitrate, is a 2nd line therapy in Pts with CHF for whom ACE inhibitors are contraindicated. See Congestive heart failure.


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In studies published in the May--August 2004 issue of International Reviews of Immunology and the October 2003 issue of Clinical Immunology, he noted that pharmaceuticals such as the heart drug procainamide and the antihypertensive agent hydralazine cause lupus in some people, and demonstrated that lupus-like disease in mice exposed to these drugs is linked with DNA methylation alterations and interruption of signaling pathways similar to those in people.
Epigenetics: the science of change by Weinhold, Bob / Environmental Health Perspectives
Researchers hypothesize that hydralazine, BiDil's other component, relaxes blood vessels while also, as an antioxidant, keeping nitric oxide active.
The race to prescribe: drug for African Americans may debut amid ... by Harder, Ben / Science News
The drug is BiDil, an experimental combination of two already approved drugs, isosorbide dinitrate (Isordil), which provides nitric oxide, and hydralazine (Apresoline), which helps the body better use nitric oxide.
African-American women & heart health by National Women's Health Report
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