hydralazine


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Related to hydralazine: labetalol

hydralazine

 [hi-dral´ah-zēn]
an antihypertensive agent and vasodilator, administered orally, intramuscularly, or intravenously as the hydrochloride salt in treatment of peripheral vascular disease, essential and early malignant hypertension, thrombophlebitis, and other conditions in which dilation of blood vessels of the extremities is desired. Dosage is adjusted to the individual patient's response. blood pressure should be checked frequently, especially during parenteral administration. Side effects are rare with therapeutic doses, but the drug must be administered with caution to patients with coronary artery disease, advanced kidney damage, and existing or incipient stroke syndrome.

hydralazine

/hy·dral·a·zine/ (hi-dral´ah-zēn) a peripheral vasodilator used in the form of the hydrochloride salt as an antihypertensive.

hydralazine

(hī-drăl′ə-zēn′)
n.
An antihypertensive drug, C8H8N4.

hydralazine

Therapeutics A vasodilator which, with isosorbide dinitrate, is a 2nd line therapy in Pts with CHF for whom ACE inhibitors are contraindicated. See Congestive heart failure.

hydralazine

A drug that causes arteries to widen (vasodilatation) and can be used as an adjunct to the treatment of high blood pressure (HYPERTENSION) and moderate degrees of HEART FAILURE. It is seldom used alone. The drug is on the WHO official list. A brand name is Apresoline.

hydralazine

an antihypertensive and vasodilator drug that relaxes arteriolar smooth muscle by direct action. It is used as the hydrochloride in peripheral vascular disease, thrombophlebitis and congestive heart failure.
References in periodicals archive ?
This study aimed to compare the antihypertensive effects of labetalol, nicardipine, and hydralazine in this patient population.
Increasing the speed, reducing the cost of experimentation and examination of the samples, reducing the use of toxic solvents, as well as the desirable accuracy and sensitivity of this method, are some of its main advantages," described Hatami in regard to the benefits of using nanoparticles in Hydralazine.
Treatment with hydralazine may produce a clinical picture simulating systemic lupus erythematosus (SLE) including glomerulonephritis.
Additionally, treating physicians could choose conventional therapies for their patients, including diuretics, digoxin, ACE inhibitors, angiotensin II receptor blockers, aldosterone blockers, Beta-blockers, nitrates, and/or hydralazine.
4) Hydralazine reproduces the lupus ERK path-way, signaling abnormality and its effects on DNA methyltransferase expression, and inhibiting this pathway induces autoimmunity.
Less than a month later, NitroMed went public, raising $66 million (even though isosorbide dinitrate and hydralazine are available separately in generic formulations, making it possible to closely approximate NitroMed's combination at a cost of about 44 cents per dose).
Patients who cannot take ACE inhibitors may get a nitrate and/or a drug called hydralazine, each of which helps relax tension in blood vessels to improve blood flow.
For example N-acetylation, which occurs with a number of drugs, such as the antitubercular isoniazid and the cardiovascular agents hydralazine and procainamide, shows a bimodal distribution 40:60 between extensive and poor metabolisers in caucasians, while more than 90% + of Japanese and Canadian Inuit are extensive metabolisers.
Purdue professor Riyi Shi is examining the effects of hydralazine on acrolein, a compound that can affect the central nervous system and damage nerve cells.
The A-Heft Trial, entitled, "Combination of Isosorbide Dinitrate and Hydralazine in Blacks with Heart Failure" was published in the New England Journal of Medicine in November 2004.
In addition to many of the [beta]-blockers, other cardiovascular drugs she listed as relatively safe in pregnancy include digoxin, calcium channel blockers, procainamide, hydralazine, methyldopa, and furosemide.
In studies published in the May--August 2004 issue of International Reviews of Immunology and the October 2003 issue of Clinical Immunology, he noted that pharmaceuticals such as the heart drug procainamide and the antihypertensive agent hydralazine cause lupus in some people, and demonstrated that lupus-like disease in mice exposed to these drugs is linked with DNA methylation alterations and interruption of signaling pathways similar to those in people.