hydralazine


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Related to hydralazine: labetalol

hydralazine

 [hi-dral´ah-zēn]
an antihypertensive agent and vasodilator, administered orally, intramuscularly, or intravenously as the hydrochloride salt in treatment of peripheral vascular disease, essential and early malignant hypertension, thrombophlebitis, and other conditions in which dilation of blood vessels of the extremities is desired. Dosage is adjusted to the individual patient's response. blood pressure should be checked frequently, especially during parenteral administration. Side effects are rare with therapeutic doses, but the drug must be administered with caution to patients with coronary artery disease, advanced kidney damage, and existing or incipient stroke syndrome.

hydralazine

/hy·dral·a·zine/ (hi-dral´ah-zēn) a peripheral vasodilator used in the form of the hydrochloride salt as an antihypertensive.

hydralazine

(hī-drăl′ə-zēn′)
n.
An antihypertensive drug, C8H8N4.

hydralazine

Therapeutics A vasodilator which, with isosorbide dinitrate, is a 2nd line therapy in Pts with CHF for whom ACE inhibitors are contraindicated. See Congestive heart failure.

hydralazine

A drug that causes arteries to widen (vasodilatation) and can be used as an adjunct to the treatment of high blood pressure (HYPERTENSION) and moderate degrees of HEART FAILURE. It is seldom used alone. The drug is on the WHO official list. A brand name is Apresoline.

hydralazine

an antihypertensive and vasodilator drug that relaxes arteriolar smooth muscle by direct action. It is used as the hydrochloride in peripheral vascular disease, thrombophlebitis and congestive heart failure.
References in periodicals archive ?
A number of different analytical procedures have been developed for the determination of hydralazine from pharmaceutical preparations and biological fluids including titrimetry [1-5], spectrophotometry [6-10], spectroflorometry [11], electrochemical at preanodised screen printed carbon electrode [12], electrochemical [13-14], high performance liquid chromatography [15-17] and gas chromatography (GC) [18-20].
KEY WORDS: Hydralazine, Labetalol, Mean arterial pressures, Pregnancy induced hypertension.
Conclusion: The use of either hydralazine or nifidipine controlled BP in the target time period but hydralazine was more efficacious.
1-3) In one study, up to 73% of hydralazine-induced systemic lupus erythematosus (SLE) patients were HLA-DR4 positive, and, "If the slow acetylators treated with Hydralazine were analysed as one group, it was observed that all women with DR4 developed Hydralazine-induced SLE.
We will compare the efficacy of intravenous hydralazine and intravenous labetalol for acutely lowering blood pressure in pregnancy.
The primary objective of this study was to compare the effects of labetalol, nicardipine, and hydralazine on time to target blood pressure before alteplase administration in patients with acute ischemic stroke.
Increasing the speed, reducing the cost of experimentation and examination of the samples, reducing the use of toxic solvents, as well as the desirable accuracy and sensitivity of this method, are some of its main advantages," described Hatami in regard to the benefits of using nanoparticles in Hydralazine.
The new findings show that hydralazine also delays onset of multiple sclerosis in mice and reduces the severity of symptoms by neutralizing acrolein.
Elsewhere in the world, intravenous labetalol has been available for many years and is often the first line of treatment of severe hypertension in pregnancy, mainly because of its favourable side-effect profile of less maternal hypotension and tachycardia compared with hydralazine and other drugs (2).
Hydralazine, which had fallen out of favor as an antihypertensive, has regained popularity as part of combination therapy for heart failure in African Americans following the benefits seen in the African-American Heart Failure Trial (N.
A study comparing the formulations of isosorbide dinitrate (ISDN) and hydralazine (HYD) used in V-HeFT I and V-HeFT II, and BiDil, the proprietary fixed dose combination, used in the African American Heart Failure Trial (A-HeFT) demonstrated no bioequivalence.
In studies published in the May--August 2004 issue of International Reviews of Immunology and the October 2003 issue of Clinical Immunology, he noted that pharmaceuticals such as the heart drug procainamide and the antihypertensive agent hydralazine cause lupus in some people, and demonstrated that lupus-like disease in mice exposed to these drugs is linked with DNA methylation alterations and interruption of signaling pathways similar to those in people.