huperzine A


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huperzine A

Chinese medicine
An ACE (acetylcholinesterase)-inhibiting sesquiterpene alkaloid found in the plant firmoss (Huperzia serrata). While not FDA-approved for such, it is sold in the US as a memory-enhancing dietary supplement; it is used in traditional Chinese medicine for oedema, fever and blood dyscrasia. Like tacrine, HA increases synaptic acetylcholine by inhibiting acetylcholinesterase; early data suggests that it may have some benefit in patients with Alzheimer's disease, epilepsy and in myasthenia gravis.

Adverse effects
Mild cholinergic effects, as well as dyspnoea, chest pain, rash, pruritus, gastritis, diarrhoea, vomiting, hyperactivity and insomnia.

huperzine A (hōōˑ·pr·zēn),

n a potent alkaloid obtained from the
Huperzia serrata club moss; used to improve memory both in healthy individuals and in those suffering from memory loss. Precaution advised for those with high blood pressure, kidney disease, and liver disease. Self-medication is not advised.
References in periodicals archive ?
BIS-001 is a highly potent form of huperzine A, a synthetic extract of a traditional Chinese medicine with a long history of safe use.
Q My sister takes a supplement called huperzine A because she heard it helps preserve memory as you age.
A Huperzine A is a dietary supplement made from a type of club moss.
Q Is huperzine A helpful for people with memory problems?
Additionally, the line includes Omega 3 Power, which provides 1,600 mg of omega 3 fatty acids from ultra-purified fish oil; and Brain & Memory Power Boost, which includes N-Acetyl-Cysteine (NAC), phosphatidylserine, huperzine A and acetyl-l-carnitine, vinpocetine and gingko biloba.
Huperzine A (HupA) is a reversible and selective inhibitor of acetylcholinesterase (AChE), and it has multiple targets when used for Alzheimer's disease (AD) therapy.
The AChE activity was found to be significantly reduced in both the cortex and hippocampus, although this activity was less potent than that of reference inhibitor huperzine A (0.
Huperzine A can also be helpful in people with frequent "senior moments," the age-related gap in mental recall that's common with aging.
Washington, August 26 (ANI): Scientists at Yale University have developed the first practical method to create a compound called huperzine A, which occurs naturally in a species of moss found in China, believed to treat Alzheimer's disease.
com's "Product Review: Supplements for Memory & Cognition Enhancement," which focuses on three ingredients that have shown some promise in improving memory: Ginkgo biloba, huperzine A, and acetyl-L-carnitine.
Huperzine A is a potent, selective, reversible inhibitor of acetylcholinesterase.
The other half includes some familiar substances like DHA (an omega-3 fatty acid found in fish), choline (a type of fat found in many foods, but possibly deficient in some older people), bilberry extract (purported to improve circulation) and huperzine A (a chemical extracted from herbs undergoing testing for use in treating Alzheimer's disease), grape seed extract, and some less familiar herbs like bacopa and vinpocetine.