hungry bones syndrome

hungry bones syndrome

Post-parathyroid surgery recalcification tetany Metabolism Transient hypoparathyroidism due to resection of significant portions of a hyperactive parathyroid gland; HBs follow high pre-operative PTH–due to excess PTH secretion as occurs in parathyroid hyperplasia and adenoma, high alk phos and extensive bone demineralization, resulting in a rapid 'rebound' recalcification of bones after prolonged hypocalcemia; bone hunger is exacerbated by a pre-existing compromise in renal function Radiology Mottled bone hypodensity Lab ↑ Calcitriol, ↓↓↓ Ca2+–eg, 1.5 mmol/L–US: 6 mg/dl or lower, ↓ phosphorus, ↓ magnesium, reactive ↑ in PTH–if there is residual secretion; the danger lies in attributing Sx to acidosis, which may accompany and exacerbate the complex Treatment Vitamin 1,25(OH)D₂