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tr.v. human·ized, human·izing, human·izes
a. To modify (a nonhuman compound, cell, organ, or organism) such that some of its components are replaced with human forms of those components, usually by means of genetic engineering.
b. To replace most of the variable region of (a monoclonal antibody from a nonhuman source) with a human sequence of amino acids so that the resulting antibody is more compatible with the human immune system.

hu′man·i·za′tion (-mə-nĭ-zā′shən) n.
hu′man·iz′er n.


Chemically altered to resemble natural human amino acid sequences. It applies to proteins or polypeptides derived from animals, e.g., mice, that are altered to reduce their antigenic potential.
References in periodicals archive ?
The basic idea of all my writing is to humanize my characters," he says.
The left has had a continuing love affair with the idea of having its own political party, and this has created a serious impediment to the creation of a coherent and effective movement to humanize our society," he writes.
By helping young people gain a sense of the personality of the victim and the enduring agony suffered by murder victims' survivors, we humanize the murdered, we return to them the individuality stolen by both the brevity of a news account and our numbness to the horror of the loss - a numbness born of the sheer frequency and heartlessness of the killing.
Humanize , new from Que Publishing, provides proven strategies for using social media to create comprehensive change and opportunities for growth.
Under the agreement, Protein Design will humanize one or more murine antibodies directed to a single target.
Nasdaq: IMGN) today announced that sanofi-aventis has licensed non-exclusive rights to use ImmunoGen's proprietary resurfacing technology to humanize antibodies.