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human placental lactogen |
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lactogen /lac·to·gen/ (lak´to-jen) any substance that enhances lactation.
human placental lactogen a hormone secreted by the placenta; it has lactogenic, luteotropic, and growth-promoting activity, and inhibits maternal insulin activity.
human placental lactogen (HPL), a placental hormone that may be deficient in certain abnormalities of pregnancy. The normal concentrations of this hormone in serum after the fifth week of pregnancy are 0.5 μg/mL and increase to approximately 8 μg/mL at the time of delivery. Also called chorionic somatomammotropin. lactogen [lak´to-jen] any substance that enhances lactation. human placental lactogen (HPL) (hPL) a hormone secreted by the placenta, which disappears from the blood immediately after delivery. It has lactogenic, luteotropic, and growth-promoting activity, and inhibits maternal insulin activity during pregnancy.
human placental lactogen Chorionic somatomammotropin, hPL, human placental lactogen, human chorionic somatomammotropin A hormone produced during implantation of a fertilized egg, and secreted by the placenta; hPL regulates and coordinates
fetal growth and metabolism and maternal metabolism Maternal effects Relative insulin resistance, ↑ circulating free fatty acids; hPL may optimize metabolism of nutrients by the fetus in 1st half of pregnancy; in 2nd half,
there is little correlation between hPL levels and fetal well-being; hPL stimulates milk production and breast enlargement, and is somatotopic and luteotropic; urine and plasma HPL levels reflect placental size and are higher in diabetic mothers Ref
range Rises during gestation, plateauing at 37 wks at 10 mg/mL; ♂ <0.5 mg/mL; non-pregnant ♀ <0.5 mg/mL; wks of gestation 5-27 <4.6 mg/mL; 28-31 wks, 2.4-6.1 mg/mL; 32-35 wks, 3.7-7.7 mg/mL; 36 wks to term, 5-8.6 mg/mL; hPL is
↓ in postmaturity syndrome, retarded growth, toxemia of pregnancy, threatened abortion; it is ↑ DM, Rh isoimmunization, hydatiform mole, choriocarcinoma Critical value <4 μg/mL after 30 wks gestation Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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