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hormone-sensitive lipase

   Also found in: Acronyms, Wikipedia 0.01 sec.
hormone-sensitive lipase,
an enzyme that catalyzes the release of fatty acids from adipose tissues.


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The resulting high tissue concentrations of cAMP activate a fat-breakdown hormone called hormone-sensitive lipase, which promotes lipolysis.
Lipolytic hormones activate adenylate cyclase, resulting in increased synthesis of cAMP, leading to activation of cAMP-dependant protein kinase and activation of hormone-sensitive lipase (HSL), so named because of its responsiveness to insulin and catecholamines (Steinberg and Khoo, 1977).
s energy supply also decreases due to the fact that cAMP activates protein Kinase A which phosphorylates(making something active) hormone-sensitive lipase.
 
 
 
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