The ability of GTx-758 to reduce serum free testosterone well below levels achieved with standard LHRH therapy may result in improved tumor control in first line therapy as well as allow for the use of GTx-758 for second line hormonal manipulation
in men with advanced prostate cancer," said Ronald A.
Before the advent of non-surgical endoluminal therapies for pelvic congestion syndrome medical therapy with hormonal manipulation
was the first-line therapy.
1] Hormonal manipulation
, based on androgen deprivation and anti-androgen therapy, is the initial cornerstone of medical management of locally advanced or metastatic prostate cancer.
may prove to provide relief for women with chronic, cyclic irritable bladder symptoms, results of a University of Washington pilot study suggested.
Since the growth of prostate cancer is testostecrone-dependent (approximately 95% of testosterone is produced by the testes, with the remainder coming from the adrenals), hormonal manipulation
has been the mainstay of plliative treatment.