Enhancer of zeste homolog
2 (EZH2)-mediated epigenetic regulation and EZH2-dependent oncogenesis.
Expression of CEN is dependent on expression of FLO, the homolog
of UNI (Bradley et al.
in addition to their potency in apoptosis control, evidenced by the disastrous in vivo consequences of Bcl2 gene translocation into immunoglobulin transcription control sequences, their importance is further underscored by the fact that mammalian viruses appear to have evolved the capacity to manipulate the activities of Bcl-2 family members by expressing their own Bcl-2 homologs
Additional mutations identified in this cohort were mapped to the following genes: APC (n = 3), PIK3CA (n = 2), ataxia telangiectasia mutated (ATM) (n = 2), and neuroblastoma RAS viral (v-ras) oncogene homolog
(NRAS) (n = 1).
Unlike two-headedness, this condition does not result from partially fused twins; it stems from problems early on in embryonic development connected to a protein signal called sonic hedgehog homolog
, or SHH.
At the molecular level, COC administration resulted in a significant attenuation of PTEN (phosphatase and tensin homolog
deleted on chromosome 10) and upregulation of phospho-Akt and c-Raf levels in the heart.
BRaf (v-raf murine sarcoma viral oncogene homolog
B1) is a serine/threonine kinase that belongs to the Ras-Raf-MEK-ERK pathway involved in the transduction of mitogenic signals from the cell membrane to the nucleus.
Collins gave the example of a mutation in a gene called MutL homolog
1, colon cancer, nonpolyposis type 2 (MLH1) that's known to increase a person's lifetime risk of developing colon cancer from an average of about 6 percent to around 60 percent.
There was also a group of genes that were involved in the pathogenesis of vascular disease, including those associated with the clotting independent signaling of F3, which included v-fos FBJ murine osteosarcoma viral oncogene homolog
(FOS, Unigene accession no.
Participating companies would commit to reduce and work toward ultimately eliminating facility emissions and product content of PFOA, PFOA precursors and related higher homolog
In Drosophila, a PLCb4 homolog
interacts with clock proteins and underlies the mechanism for an oscillation in visual sensitivity.
To test this hypothesis, we isolated and investigated the function of the zebrafish gene zASIP, a homolog
of the ASIP/Bazooka/Par-3 gene that is conserved from worms to humans.