homogentisic acid


Also found in: Dictionary, Thesaurus, Legal, Acronyms, Encyclopedia, Wikipedia.

homogentisic acid

 [ho″mo-jen-tis´ik]
2,5-dihydroxyphenyl acetic acid, an intermediate product in the metabolism of tyrosine and phenylalanine, excreted in the urine in the inborn error of metabolism known as phenylketonuria.

ho·mo·gen·tis·ic ac·id

(hō'mō-jen-tis'ik as'id),
Glycosuric acid; (2,5-dihydroxyphenyl)acetic acid; an intermediate in l-phenylalanine and l-tyrosine catabolism; if made alkaline, it oxidizes rapidly in air to a quinone that polymerizes to a melaninlike material; elevated levels are observed in patients with alcaptonuria.
Synonym(s): alcapton, alkapton

homogentisic acid

/ho·mo·gen·tis·ic ac·id/ (ho″mo-jen-tis´ik) an aromatic hydrocarbon formed as an intermediate in the metabolism of tyrosine and phenylalanine and accumulated and excreted in the urine in alkaptonuria.

homogentisic acid

(hō′mō-jĕn-tĭz′ĭk)
n.
An intermediate of the metabolic breakdown of tyrosine and phenylalanine; it occurs in the urine in cases of alkaptonuria.

homogentisic acid

a compound that is an intermediate product of the metabolism of tyrosine. It forms a melanin-like staining substance in the urine of people who have alkaptonuria.

ho·mo·gen·tis·ic ac·id

(hō'mō-jen-tis'ik as'id)
An intermediate in l-phenylalanine and l-tyrosine catabolism; if made alkaline, it oxidizes rapidly in air to a quinone that polymerizes to a melaninlike material; elevated levels are observed in individuals having alcaptonuria.
Synonym(s): alcapton, alkapton.

homogentisic acid

see GARROD, A.
References in periodicals archive ?
Ochronosis results from a deficiency of homogentisic acid oxidase and leads to deposition of homogentisic acid in tissues.
Patients do not have enough of the enzyme homogentisic acid oxidase, which causes acid to build up in the body.
Accumulation of the homogentisic acid manifests itself both grossly and microscopically as black pigmentation, most commonly found in 4 locations: joints, cardiovascular system, kidney, and skin.