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homogentisic acid

   Also found in: Dictionary/thesaurus, Acronyms, Encyclopedia, Wikipedia 0.01 sec.
homogentisic acid /ho·mo·gen·tis·ic ac·id/ (ho″mo-jen-tis´ik) an aromatic hydrocarbon formed as an intermediate in the metabolism of tyrosine and phenylalanine and accumulated and excreted in the urine in alkaptonuria.
ho·mo·gen·tis·ic acid (hm-jn-tzk)
n.
An intermediate of the metabolic breakdown of tyrosine and phenylalanine; it occurs in the urine in cases of alkaptonuria. Also called alkapton.

homogentisic acid,
a compound that is an intermediate product of the metabolism of tyrosine. It forms a melanin-like staining substance in the urine of people who have alkaptonuria.

homogentisic acid [ho″mo-jen-tis´ik]
2,5-dihydroxyphenyl acetic acid, an intermediate product in the metabolism of tyrosine and phenylalanine, excreted in the urine in the inborn error of metabolism known as phenylketonuria.


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Patients do not have enough of the enzyme homogentisic acid oxidase, which causes acid to build up in the body.
Accumulation of the homogentisic acid manifests itself both grossly and microscopically as black pigmentation, most commonly found in 4 locations: joints, cardiovascular system, kidney, and skin.
 
 
 
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