homodimer


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Related to homodimer: Heterodimer

homodimer

(hō-mō-dī'mĕr),
A molecule composed of paired identical proteins.
[homo- + dimer]

homodimer

a protein composed of two identical polypeptide chains.
References in periodicals archive ?
Presentation of scientific data on the HER1 and HER3 total protein assays, the HER1:HER1 homodimer assay, the HER1:HER2 and HER2:HER3 heterodimer assays and the PI3K assay (at the 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Geneva, Switzerland in October 2008, at the AACR Targeting the PI3-Kinase Pathway in Cancer meeting in Cambridge, MA in November 2008, and at the San Antonio Breast Cancer Symposium in December, 2008).
Preliminary results of one such study in metastatic breast cancer were presented by collaborators earlier this year at ASCO ("Total HER2 and HER2 Homodimer Levels Predict Response to trastuzumab.
The data show that higher HER2 total protein and HER2 homodimer levels, as measured by HERmark, predict which patients have the best chance of responding to Herceptin, even within a population that has already been determined to be FISH+ on central laboratory testing.
Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation.
Crystal structure and deletion analysis show that the accessory subunit of mammalian DNA polymerase g, PolyB, functions as a homodimer.
The data presented this week, on the HER1 and HER3 total protein assays, the HER1:HER1 homodimer assay and the activated HER1:HER2 heterodimer assay, provide support for the use of these assays in drug development programs not only in breast cancer, our current focus, but also in other cancer types.
Development work on VeraTag(TM) assays for heterodimers of HER1:HER2 and HER2:HER3, the HER1:HER1 homodimer as well as for p95, a truncated form of HER2, and the HER3/PI3K complex is proceeding well and we expect to present data on several of these assays later in 2008.
ii) CAPN3 is likely to function as a homodimer due to its lacking a small subunit (28 kDa) (Blanchard et al.
The assay is now being developed to detect HER3, various homodimer and heterodimer pairs, and other signaling molecules.
HERmark measurements of HER2 total protein and HER2 homodimer levels will be compared with the results of IHC and/or FISH testing as well as response to treatment with Herceptin.
It has been shown that a ligand-steroid hormone receptor complex forms a homodimer once CORT binds to the steroid hormone receptor.