To detect Hg(II) ion selectively, we modified the surface of the gold nanoparticle with mercaptopropionic acid (MPA) and homocystine
(bound to the gold nanoparticle surface through Au-S bond) and we added a chelating ligand 2,6-pyridinedicarboxylic acid (PDCA), to the solution, as we discussed before.
Homocysteine and homocystine
, in large quantities, may be harmful.
Homocysteine can react with molecular oxygen, generating homocystine
and reactive oxygen species.
For cystine and homocystine
, quantitative, see 82131, 82136, 82139)
The pathways were altered by feeding either methionine or homocystine
(H-H) in conjunction with either folic acid (FA) or choline deficiency.
We also investigated for prothrombotic states, like Anti thrombin III concentrations, Homocystine
levels, Factor VIII, Factor V Leiden, albumin, fibrinogen, and, platelet count, platelet aggregation, and bleeding time were normal.
Homocysteine is detected in amino acid profiles as its oxidized homodimer, homocystine
The patient's plasma homocystine
concentration was 48 jwmol/L (reference interval, <2 [micro]mol/L), and her urine homocystine
concentration was also markedly increased.
Isotopically labeled MMA and homocystine
standards were purchased from Cambridge Isotope Laboratories and isotopically labeled MCA from CDN Isotopes.
HHCY was induced by 2 different diets (Altromin) that were administered for 12 weeks: methionine at 24 g/kg food and homocystine
at 20 g/kg food.
The 2 other groups were fed with homocystine
-enriched diets, containing 10 g (Hcy1) or 20 g (Hcy2) homocystine
(Sigma) per kg food (corresponding to 1% and 2% Hcy).
Relative roles of albumin and ceruloplasmin in the formation of homocystine
, homocysteine-cysteine-mixed disulfide, and cystine in circulation.