Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine
18) Another study looked at the effects of carnosine and related compounds on the formation of AGEs in uremic patients who had undergone peritoneal dialysis and found that carnosine slowed the development of AGEs better than the similar peptides anserine and homocarnosine
Protective effects of carnosine, homocarnosine
and anserine against peroxyl radical-mediated Cu,Zn-superoxide dismutase modification.
Effect of carnosine homocarnosine
and anserine on hydroxylation of the guanine moiety in 2'-deoxyguanosine, DNA and nucleohistone with hydrogen peroxide in the presence of nickel(II).
Specifically, although under appropriate conditions both isoforms catalyze the hydrolysis of the dipeptide carnosine ([beta]-alanyl-L-histidine), only serum carnosinase is able to hydrolyze homocarnosine ([gamma]-aminobutyryl-L-histidine) (2, 9,10).
It is believed that carnosine and homocarnosine have the ability to protect neuronal cells against ischemic injury (11) and oxidative stress (12,13) as well as to increase their resistance toward functional exhaustion and accumulation of senile features (14).
Currently, the possible relationships between cerebral damage, neurocognitive function, carnosine and homocarnosine concentrations, and serum carnosinase activity during (open) heart surgery are not well understood.
0 mmol/L), after which homocarnosine (30 mmol/L) prewarmed to 37[degrees]C was added.
In preliminary tests we observed that nonhydrolyzed homocarnosine contributed to fluorescence and that calibration curves prepared in sample buffer showed slightly higher fluorescence values compared with calibration curves prepared in either heparin plasma or serum.
Protective effects of carnosine and homocarnosine
on ferritin and hydrogen peroxide-mediated DNA damage.
Carnosine and its variants (anserine, homocarnosine
, N-acetyl carnosine, and carcinine) contain alanine and histidine.
Neither D-carnosine, (beta-alanyl-D-histidine), homocarnosine
, anserine, nor beta-alanine had the same effects as carnosine on human fibroblasts.