HOXA11

(redirected from homeobox protein HOXA11)

HOXA11

A gene on chromosome 7p15.2 that encodes a sequence-specific transcription factor of a developmental regulatory system, which provides cells with specific positional identities on the anterior-posterior axis and appears to be involved in gene expression, morphogenesis and differentiation. HOX11 is involved in regulating uterine development and is required for female fertility.

Molecular pathology
HOXA11 mutations cause radio-ulnar synostosis
with amegakaryocytic thrombocytopenia.
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