homeobox genes


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homeobox genes

A highly CONSERVED family of genes, found in a large range of different species, including insects. Homeobox genes are expressed early in embryonic development and are the determinants of body shape. These genes divide the early embryo into fields of cells each with the potentiality to develop into a particular part such as an arm, leg, tissue or organ. This is the key to the long-unexplained problem of how bodily configuration is determined by genetics. Mutations in homeobox genes cause severe bodily defects such as PHOCOMELIA.
References in periodicals archive ?
ROUGH SHEATH2: a Myb protein that represses Knox homeobox genes in maize lateral organ primordia.
The rough sheath2 gene negatively regulates homeobox gene expression during maize leaf development.
Upregulation of the cardiac homeobox gene Nkx2-5 (CSX) in feline right ventricular pressure overload.
5: a novel murine homeobox gene expressed in early heart progenitor cells and their myogenic descendants.
CS is associated with mutations in the homeobox gene HLXB9 and may segregate in families as an autosomal dominant trait, mainly as a result of haploinsufficiency (4, 5).
Involvement of the HLXB9 homeobox gene in Currarino syndrome.
Thus, certain retinoic acid receptors control the specific homeobox genes that regulate the timing and coordination of craniofacial development.
Lovejoy and his colleagues used chemical probes injected into mouse embryos to establish that one pair of homeobox genes displays a distinctive molecular footprint in the thumb bones, while another pair leaves a unique calling card in bones of the forearm and the remaining four fingers.
Other researchers later discovered homeobox genes with identical DNA sequences in mice, humans and other vertebrates.