homeobox gene


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Related to homeobox gene: Hox gene

homeobox gene

n.
One of a group of genes with a characteristic sequence of nucleotides coding an amino acid sequence that functions in binding to DNA. Homeobox genes are involved in the formation of bodily segmentation during embryologic development.

homeobox gene

Any transcription factor that regulates the growth, differentiation, replication, and movement of cells in the body. These genes influence both normal and abnormal embyological development and the development or suppression of malignant tumors.
See also: gene
References in periodicals archive ?
Shoot meristem size is dependent on inbred background and presence of the of the maize homeobox gene, knotted1.
Roles of the middle domain-specific WUSCHEL-RELATED HOMEOBOX genes in early development of leaves in Arabidopsis.
Cardiac expression of the ventricle-specific homeobox gene Irx4 is modulated by Nkx2-5 and dHand, Dev Biol 2000; 217: 266-77.
A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis.
Any lingering doubts that homeobox genes are important regulators of vetebrate [development] should be dispelled" by Cappechi's study, write Hogan and her Utah colleague Christopher Wright in a commentary accompanying the NATURE paper.
Two other possible mechanisms are a deficiency in retinoic acid and altered expression of homeobox genes.
In any case, mutations in homeobox genes cannot explain the origin of body form.
Homeobox genes control the general shape of the fetal body.
Oviducts of adults treated neonatally with genistein had abnormal morphology with gene expression patterns similar to that observed in the posterior cervical and vaginal tissues, as indicated by altered Hoxa gene patterning during the time of treatment and dramatic, permanent up-regulation of homeobox genes (e.
For example, in species ranging from humans to mice to fruit flies, the homeobox genes, a collection of genes that guides the development of the embryo by turning on other genes, help distinguish the animal's eventual head from its tail--and all points in between.
The chemical structure of Pax-3 resembles that of another gene family, the homeobox genes, which play a role in overall body development in the early embryos of everything from mice and fruitflies to humans (SN: 4/20/91, p.