homeobox


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ho·me·o·box

(hō'mē-ō-boks),
A highly conserved DNA sequence of about 180 base pairs near the 3' end of specific homeotic genes; it encodes a DNA-binding domain that allows the homeobox proteins to bind to and regulate gene expression in development.
Synonym(s): homeodomain

homeobox

(hō′mē-ə-bŏks′)
n.
A sequence of DNA encoding a protein structure that binds to specific parts of DNA and affects transcription of DNA into RNA.

homeobox

a conserved DNA motif of about 180bp encoding a protein domain (approximately 60 amino acids) that binds to DNA. The homeobox is a characteristic of HOMEOTIC GENES and is found in most EUKARYOTES.
References in periodicals archive ?
The most significant change in biological functions took place in gene expression functions, as could be expected from the effects observed on homeobox transcription factors.
A dominant mutation in the maize homeobox gene, Knotted-1, causes its ectopic expression in leaf cells with altered fates.
Retinoic acid likely acts in this capacity by binding to receptors that regulate the expression of homeobox genes.
A homeobox is a region of a gene that enables it to control other genes crucial to a plant's final form and function.
10] Human genes: TLX3, T-cell leukemia homeobox 3; FOXE3, forkhead box E3.
Pelvic loss in sticklebacks (Gasterosteidae) has been attributed to deletion of a cis-acting regulatory region adjacent to the Pituitary homeobox transcription factor 1 gene (Pitx1).
Immunohistochemical staining of tumour tissue was negative for prostate-specific antigen (PSA) and prostate-specific acid phosphatase, strongly positive for cytokeratin (CK) 7/20/ carcinoembryonic antigen (CEA), strong nuclear positive for caudal-related homeobox 2 (CDX2) and negative staining for CK5/6.
Advances in the field of genetics have estimated that about 2% of idiopathic short stature is related to haploinsufficiency of the short stature homeobox (SHOX) gene, which is found on the short arm of the X and Y chromosomes in the pseudoautosomal region.
Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, Rieg, involved in Rieger syndrome.
Paleobiologists bring many analytical tools to bear in interpreting the fossil record and the book introduces the latest techniques, from multivariate investigations of biogeography and biostratigraphy to engineering analysis of dinosaur skulls, and from homeobox genes to cladistics.