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holoprosencephaly |
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holoprosencephaly /holo·pros·en·ceph·a·ly/ (-pros″en-sef´ah-le) developmental failure of cleavage of the prosencephalon with a deficit in midline facial development and with cyclopia in the severe form; sometimes due to trisomy 13.
holoprosencephaly [hol′ōpros′ensef′əlē] Etymology: Gk, holos + pro, before, enkephalos, brain a congenital defect caused by the failure of the prosencephalon to divide into hemispheres during embryonic development. It is characterized by multiple midline facial defects, including cyclopia in severe cases. It can also be caused by an extra chromosome in the 13-15 or D group, manifested as one of many developmental defects. See also trisomy 13. holoprosencephalic, holoprosencephalous, adj. holoprosencephaly (hō´lōpros´ n a congenital defect caused by the failure of the prosencephalon to divide into hemispheres during embryonic development. It is characterized by multiple midline facial defects, including cyclopia in severe cases. holoprosencephaly developmental failure of cleavage of the prosencephalon with a deficit in midline facial development and with cyclopia in the severe form. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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MRI is also the best method for identifying intracranial anomalies associated with meningoencephalocele: holoprosencephaly, DandyWalker malformation, aqueductal stenosis, agenesis of the corpus callosum, and other midline abnormalities. Helms, along with former UCSF researcher Dwight Cordero, MD, who is now a perinatologist at Albert Einstein Medical School, and their colleagues studied a birth defect called holoprosencephaly, or HPE, that results when the embryonic brain fails to properly divide into two hemispheres. |
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