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holoprosencephaly

   Also found in: Acronyms, Wikipedia 0.04 sec.
holoprosencephaly /holo·pros·en·ceph·a·ly/ (-pros″en-sef´ah-le) developmental failure of cleavage of the prosencephalon with a deficit in midline facial development and with cyclopia in the severe form; sometimes due to trisomy 13.
hol·o·pros·en·ceph·a·ly (hl-prsn-sf-l, hl-)
n.
Failure of the forebrain to divide into hemispheres or lobes causing insufficient development of facial characteristics such as the nose, lips, and palate; in severe cases, cyclopia can occur.

holoprosencephaly
[hol′ōpros′ensef′əlē]
Etymology: Gk, holos + pro, before, enkephalos, brain
a congenital defect caused by the failure of the prosencephalon to divide into hemispheres during embryonic development. It is characterized by multiple midline facial defects, including cyclopia in severe cases. It can also be caused by an extra chromosome in the 13-15 or D group, manifested as one of many developmental defects. See also trisomy 13. holoprosencephalic, holoprosencephalous, adj.

holoprosencephaly (hō´lōpros´n-sef´lē),
n a congenital defect caused by the failure of the prosencephalon to divide into hemispheres during embryonic development. It is characterized by multiple midline facial defects, including cyclopia in severe cases.

holoprosencephaly
developmental failure of cleavage of the prosencephalon with a deficit in midline facial development and with cyclopia in the severe form.


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MRI is also the best method for identifying intracranial anomalies associated with meningoencephalocele: holoprosencephaly, DandyWalker malformation, aqueductal stenosis, agenesis of the corpus callosum, and other midline abnormalities.
Helms, along with former UCSF researcher Dwight Cordero, MD, who is now a perinatologist at Albert Einstein Medical School, and their colleagues studied a birth defect called holoprosencephaly, or HPE, that results when the embryonic brain fails to properly divide into two hemispheres.
 
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