holoprosencephaly

holoprosencephaly /holo·pros·en·ceph·a·ly/ (-pros″en-sef´ah-le) developmental failure of cleavage of the prosencephalon with a deficit in midline facial development and with cyclopia in the severe form; sometimes due to trisomy 13.

hol·o·pros·en·ceph·a·ly (h

-pr

n-s

-l

, h

Failure of the forebrain to divide into hemispheres or lobes causing insufficient development of facial characteristics such as the nose, lips, and palate; in severe cases, cyclopia can occur.

holoprosencephaly

[hol′ōpros′ensef′əlē]

Etymology: Gk, holos + pro, before, enkephalos, brain

a congenital defect caused by the failure of the prosencephalon to divide into hemispheres during embryonic development. It is characterized by multiple midline facial defects, including cyclopia in severe cases. It can also be caused by an extra chromosome in the 13-15 or D group, manifested as one of many developmental defects. See also trisomy 13. holoprosencephalic, holoprosencephalous, adj.

holoprosencephaly [hol″o-pros″en-sef´ah-le]

a developmental anomaly consisting of failure of cleavage of the prechordal mesoderm with a deficit in the forebrain and midline facial development; in the severe form there may be cyclopia. It is sometimes associated with trisomy 13 syndrome.

The facial features in holoprosencephaly. The eyes are close together and there is a midline cleft lip. From Mueller and Young, 2001.

Mentioned in	?		References in periodicals archive	?		Medical browser	?		Full browser	?
Aarskog syndrome acute coronary syndrome Adams-Stokes syndrome Adie's syndrome adrenogenital syndrome afferent loop syndrome Ahumada-del Castillo syndrome Alagille syndrome Albright's syndrome Alport's syndrome amnestic syndrome Apert's syndrome Congenital Brain Defects de Lange's syndrome diabetic embryopathy Edwards' syndrome Kimmelstiel-Wilson syndrome Klinefelter's syndrome Klippel-Feil syndrome	She was later diagnosed with Holoprosencephaly and had to be fitted with a tracheostomy tube to aid her breathing and a gastrostomy to feed. The machine that will give my Kara new lease of life; NOW WE'LL BE ... by Daily Post (Liverpool, England) Absence of the anterior portion of the corpus callosum with presence of the posterior portion only result from dysgenesis associated with holoprosencephaly and when there is a focal cortical infarct with fibres that cross through the anterior corpus callosum (local atrophy). Spinal segmental dysgenesis by Andronikou, S. / South African Journal of Radiology Chapters cover: chromosomal translocations and fusion genes in human soft tissue, carrier screening for B-Thalassemia, genetic testing for late-onset disorders, lobar holoprosencephaly and behavioral disorders, medullary thyroid cancer as a paradigm for genetic screening of inherited cancers, and learning disabilities in low birth weight children. Trends in birth defects research by SciTech Book News	holoacardius amorphus holoarthritis holoblastic Holocalyx glaziovii Holocaust holocephalic holocord holocrine holocrine gland holodiastolic Holodomor Famine holoendemic holoenzyme hologram Holographic Memory Release holographic reconstruction Holographic Repatterning holography hologynic hologynic inheritance Holomenopon holometabolous holomyarian holon holophytic holoprosencephaly holoprotein holoptic holorachischisis holosystolic holotopy holotropic breathwork holotype holozoic Holstein Holstein Cow Pattern Holstein udder plague Holstein-Friesian holsteiner Holt-Oram syndrome Holter monitor Holter monitoring Holthouse's hernia Holtz-Celsus procedure Holtzman Ink Blot Test Holtzman inkblot technique holy grail hom(o)- hom- Homalopsinae homaluria	Holonomic constraints Holonomic Quantum Computation holonomic system Holonomic Systems Holons Holons Holons holonym holonymy Holoparasitism Holoparasitism Holophanerous Holophotal Holophotal Holophote Holophote Holophrase holophrases Holophrasis holophrastic holophyte holophyte holophyte holophytic holophytic holophytic Holophytic nutrition Holophytic nutrition holoplankton holoplankton holoprosencephaly Holoprosencephaly 2 Holoprotein Holoptic Holoptychidae holopulping process holorachischisis Holoregmia Holorhinal Holorhinal holorhinal nares holorhinal nares Holosiderite holospondyly Holostean Holostean Holostei Holostei Holosteric Holostomata Holostomate Holostomatous Holostome Holostome Holostraca holostratotype holosymmetric holosystemic holosystolic holosystolic murmur

Mentioned in

References in periodicals archive

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Aarskog syndrome
acute coronary syndrome
Adams-Stokes syndrome
Adie's syndrome
adrenogenital syndrome
afferent loop syndrome
Ahumada-del Castillo syndrome
Alagille syndrome
Albright's syndrome
Alport's syndrome
amnestic syndrome
Apert's syndrome
Congenital Brain Defects
de Lange's syndrome
diabetic embryopathy
Edwards' syndrome
Kimmelstiel-Wilson syndrome
Klinefelter's syndrome
Klippel-Feil syndrome

She was later diagnosed with Holoprosencephaly and had to be fitted with a tracheostomy tube to aid her breathing and a gastrostomy to feed.

The machine that will give my Kara new lease of life; NOW WE'LL BE ... by Daily Post (Liverpool, England)

Absence of the anterior portion of the corpus callosum with presence of the posterior portion only result from dysgenesis associated with holoprosencephaly and when there is a focal cortical infarct with fibres that cross through the anterior corpus callosum (local atrophy).

Spinal segmental dysgenesis by Andronikou, S. / South African Journal of Radiology

Chapters cover: chromosomal translocations and fusion genes in human soft tissue, carrier screening for B-Thalassemia, genetic testing for late-onset disorders, lobar holoprosencephaly and behavioral disorders, medullary thyroid cancer as a paradigm for genetic screening of inherited cancers, and learning disabilities in low birth weight children.

Trends in birth defects research by SciTech Book News