hob·nail cell (h b n l )n. A cell in a mesonephroma having a round expansion of clear cytoplasm projecting into the lumen of neoplastic tubules and a narrow, basal part containing the nucleus. |
Hobnail Cell
A cell that juts above an adjacent epithelial or endothelial surface or lining; the hobnail pattern’s significance differs according to the organ, and it can be neoplastic—as in mesonephroid-type ovarian cystadenocarcinoma, clear cell carcinoma, endometrial carcinoma, collecting duct carcinoma, mesotheliomas—or reactive, as the jutting of type II pneumocytes above the alveolar lining in lungs with diffuse alveolar damage or the bulging of succulent, secretion-filled, vacuolated, enlarged and pleomorphic apocrine cells in the lobules of a lactating breast
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