historical control

A control group that is chosen from a group of patients who were observed at some time in the past or for whom data are available through records. Historical controls are used for comparison with subjects being treated or assessed concurrently

historical control

Epidemiology A control group that is chosen from a group of patients who were observed at some time in the past or for whom data are available through records; HCs are used for comparison with subjects being treated concurrently. See Control.
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The primary study endpoint is sustained virologic response (SVR) at 12 weeks after treatment (SVR12) with 12 and eight weeks of treatment with SMV/SOF versus a historical control (patients previously treated with approved regimens containing a direct-acting antiviral, pegylated interferon and ribavirin).
The authors suggested the post-implantation loss, the decreased body weights and the incident of dead foetus are well within the historical control data range and as such the no-observed-effect-level (NOEL) was above 1225mg/kg/day for the dams and the foetuses, however these findings should not be discounted.
Results were striking, compared with a historical control group using telaprevir plus pegylated IFN plus ribavirin, with the threshold for noninferiority and superiority set at 43% , and 54%, respectively.
The efficacy of Defitelio to treat sVOD in HSCT patients is supported by data from a pivotal, multi-centre Phase 3 trial that evaluated Defitelio for the treatment of sVOD compared with a historical control group of patients who had received standard supportive care.
This study examines the rate of late-preterm birth in a hypnosis group (directed to all women) and a historical control group.
Nurses' notes were reviewed for the 6-month preassault period and a 6-month historical control period during which the patient had been clinically stable.
Further, the rate of decline of several key disease symptom indicators, including the Revised ALS Functional Rating Scale (ALSFRS-R), which measures overall functional capacity, and vital capacity, which measures breathing ability, in the arimoclomol-treated group compared favorably to a matched historical control.
Antonaglia and colleagues (2006) argue (with tenuous support of an historical control group using face-mask NIV) that the helmet is a more effective interface than face-mask for NIV in COPD.
This small sample size is inadequate to determine a normal AGD value, and there are no historical control data for AGD in male human infants using a definition of AGD comparable to the one used by Swan et al.
Although the advisory could certainly be interpreted as another instance of the FDA putting politics before science, it is just as easily read as an attempt by the FDA to maintain its historical control over drugs and devices.
take these applications into account as they describe uncertainty and sensitivity analysis, linear and nonlinear regression, generalized linear models, risk assessment with stimulus-response data, temporal data and autoregressive modeling, spatially-correlated data, sampling, probability, statistics inference, and combining environmental information such as in meta-analysis and historical control information.
If Resten-MP can significantly reduce late lumen loss at six months compared to the historical control, there is every confidence that pivotal studies would demonstrate the therapeutic value of the drug.

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