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histone

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histone /his·tone/ (his´tōn) a simple protein, soluble in water and insoluble in dilute ammonia, found combined as salts with acidic substances, e.g., the protein combined with nucleic acid or the globin of hemoglobin.
his·tone (hstn)
n.
Any of several small simple proteins that are most commonly found in association with the DNA in chromatin and contain a high proportion of basic amino acids.

histone
[his′tōn]
Etymology: Gk, histos, tissue
any of a group of strongly basic, low-molecular weight proteins that are soluble in water and insoluble in dilute ammonia and combine with DNA to form nucleoproteins. They are found in the nucleus of eukaryotic cells, where they form a complex with DNA in the chromatin and function in regulating gene activity. See also nucleosome.

histone [his´tōn]
a simple protein, soluble in water and insoluble in dilute ammonia, found combined as salts with acidic substances, such as nucleic acids or the globin of hemoglobin.

histone
a simple protein, soluble in water and insoluble in dilute ammonia, found combined as salts with acidic substances, such as in DNA where they have a structural and functional role.

histone acetylase, histone deacylase
enzymes responsible for the reversible acylation of four lysine residues near the N-terminus of histone H4.


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Sir2 removes an acetyl group attached to a specific site (lysine at position 16 or K16) on histone H4-histones are proteins that package and organize the long strands of DNA within the nucleus and also are central regulators in turning genes on and off.
In this volume, Esteller (Cancer Epigenetics Laboratory, Spanish National Cancer Research Center, Spain) presents 15 chapters discussing new developments, main features, and translational applications for disease in the field, particularly regarding DNA methylations, histone modifications, noncoding RNAs, and chromatin remodeling.
It is well known that these modifications are associated with repressed genes and can be reversed by the use of small molecules that inhibit the enzymes (called histone deacetylases or HDACs) responsible for such modifications, hence reactivating gene function.
 
 
 
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