histone


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to histone: nonhistone

histone

 [his´tōn]
a simple protein, soluble in water and insoluble in dilute ammonia, found combined as salts with acidic substances, such as nucleic acids or the globin of hemoglobin.

his·tone (H),

(his'tōn),
One of a number of simple proteins (often found in the cell nucleus); contains a high proportion of basic amino acids; soluble in water, dilute acids, and alkalies; and not coagulable by heat; for example, the proteins associated with nucleic acids in the nuclei of plant and animal tissues. They constitute about half the mass of the chromosomes of eukaryotic cells.

histone

/his·tone/ (his´tōn) a simple protein, soluble in water and insoluble in dilute ammonia, found combined as salts with acidic substances, e.g., the protein combined with nucleic acid or the globin of hemoglobin.

histone

(hĭs′tōn′)
n.
Any of several basic proteins found in association with the DNA in the chromatin of eukaryotes.

histone

[his′tōn]
Etymology: Gk, histos, tissue
any of a group of strongly basic, low-molecular weight proteins that are soluble in water and insoluble in dilute ammonia and combine with DNA to form nucleoproteins. They are found in the nucleus of eukaryotic cells, where they form a complex with DNA in the chromatin and function in regulating gene activity. See also nucleosome.

his·tone

(his'tōn)
One of a number of simple proteins (often found in the cell nucleus) containing a high proportion of basic amino acids, are soluble in water, dilute acids, and alkalies, and are not coagulable by heat.

histone

a type of simple protein that is usually basic and tends to form complexes with nucleic acids (e.g. DNA) forming NUCLEOSOMES. CHROMOSOMES of EUKARYOTES contain large quantities of histones which may regulate DNA functioning in some way. The five major histones are represented as: H1, H2A, H2B, H3 and H4.

histone

a simple protein, soluble in water and insoluble in dilute ammonia, found combined as salts with acidic substances, such as in DNA where they have a structural and functional role.

histone acetylase, histone deacylase
enzymes responsible for the reversible acylation of four lysine residues near the N-terminus of histone H4.
References in periodicals archive ?
The study addressed the interaction between mRNA and histone modification in a genome-wide scale.
A 160bp fragment of the H4 gene was amplified by using the primers H4-F02 (5'GGT ATT ACT AAG CCC GCT ATC AGA AGA3') and H4-R02 (5'GGT CTT TCT TCT GGC GTG TTC AGT GTA3') as used by Maciejewska (2006), who applied H4 histone gene for phylogenetic analysis of P.
These acetylation modifications are critical for histone nuclear import and chromatin assembly.
The report reviews key players involved in Histone Deacetylase 1 (EC 3.
Primers of chromatin modifier genes were used, including the histone acetyltransferases (P300 and CREBBP) and the histone deacetylases (HDAC1, HDAC2, and HDAC7).
Moreover, in the presence of DPI, the TPA-elicited induction of Slug was significantly blocked (Figure 4(b)), and this was accompanied by the inhibition of histone H3 acetylation (Figure 4(c)), indicating that NOX2-derived ROS participate in the TPA-elicited induction of Slug in MCF-7 cells.
Linking DNA methylation and histone modification: patterns and paradigms.
Similarly, upon expression of normal hairless protein, but not a mutant form of the hairless protein, researchers observed a drastic loss of histone methylation in human cells.
The objectives of this research were as follows: i) to observe whether the development of cloned porcine embryos could be improved by TSA treatment; ii) to analyze the relationship between embryo development and changes in histone acetylation patterns by TSA treatment; and iii) to examine the effects of TSA treatment on the expression pattern of seven genes (OCT4, ID1, H19, NNAT, PEG1, Cytokeratin 8, and Cytokeratin 18).
Pathophysiological response to hypoxia--from the molecular mechanisms of malady to drug discovery: epigenetic regulation of the hypoxic response via hypoxia-inducible factor and histone modifying enzymes.
Although plant chromatin in general and histone proteins in particular as well as plant hormone signaling have been subjects of great interest during the last decade, the number of review articles concerning the effect of plant hormones on plant chromatin pattern are limited.